Preclinical and Clinical Research Models of Prostate Cancer: A Brief Overview
department or school: Alumni
department or school: Non UBC
data provider: DSpace
identifier citation: Life 12 (10): 1607 (2022)
creator: Basak, Debasish
creator: Gregori, Lisney
creator: Johora, Fatema
creator: Deb, Subrata
issued: 2024-12-17T18:44:28Z
issued: 2022-10-14
description: The incidence and mortality from prostate cancer (PCa) are on the rise which poses a major public health concern worldwide. In this narrative review, we have summarized the characteristics of major in vitro and in vivo PCa models including their utility in developing treatment strategies. Androgens, particularly, testosterone and dihydrotestosterone (DHT) activate the androgen receptor (AR) signaling pathway that facilitates the development and progression of castration resistant PCa. Several enzymes namely, CYP17A1, HSD17B, and SRD5A are essential to furnishing DHT from dehydroepiandrosterone in the classical pathway while DHT is formed from androstanediol in the backdoor pathway. The advancement in delineating the molecular heterogeneity of PCa has been possible through the development of several in vitro and in vivo research models. Generally, tissue culture models are advantageous to understand PCa biology and investigate the efficacy and toxicity of novel agents; nevertheless, animal models are indispensable to studying the PCa etiology and treatment since they can simulate the tumor microenvironment that plays a central role in initiation and progression of the disease. Moreover, the availability of several genetically engineered mouse models has made it possible to study the metastasis process. However, the conventional models are not devoid of limitations. For example, the lack of heterogeneity in tissue culture models and the variation of metastatic characteristics in xenograft models are obviously challenging. Additionally, due to the racial and ethnic disparities in PCa pathophysiology, a new model that can represent PCa encompassing different ethnicities is urgently needed. New models should continue to evolve to address the genetic and molecular complexities as well as to further elucidate the finer details of the steroidogenic pathway associated with PCa.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/89902
note: Citation: Basak, D.; Gregori, L.;Johora, F.; Deb, S. Preclinical andClinical Research Models of ProstateCancer: A Brief Overview. Life 2022,12, 1607. https://doi.org/10.3390/life12101607Academic Editors: Ana Faustino andPaula A. OliveiraReceived: 6 September 2022Accepted: 30 September 2022Published: 14 October 2022Publisher’s Note: MDPI stays neutralwith regard to jurisdictional claims inpublished maps and institutional affil-iations.Copyright: © 2022 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).lifeReviewPreclinical and Clinical Research Models of Prostate Cancer:A Brief OverviewDebasish Basak, Lisney Gregori, Fatema Johora and Subrata Deb *Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL 33169, USA* Correspondence: sdeb@alumni.ubc.ca; Tel.: +1-224-310-7870Abstract: The incidence and mortality from prostate cancer (PCa) are on the rise which poses a majorpublic health concern worldwide. In this narrative review, we have summarized the characteristicsof major in vitro and in vivo PCa models including their utility in developing treatment strategies.Androgens, particularly, testosterone and dihydrotestosterone (DHT) activate the androgen receptor(AR) signaling pathway that facilitates the development and progression of castration resistant PCa.Several enzymes namely, CYP17A1, HSD17B, and SRD5A are essential to furnishing DHT fromdehydroepiandrosterone in the classical pathway while DHT is formed from androstanediol in thebackdoor pathway. The advancement in delineating the molecular heterogeneity of PCa has beenpossible through the development of several in vitro and in vivo research models. Generally, tissueculture models are advantageous to understand PCa biology and investigate the efficacy and toxicityof novel agents; nevertheless, animal models…
has type: Article
is shown at: 10.14288/1.0447528
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/life12101607
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
subject: prostate cancer
subject: research models
subject: preclinical
subject: clinical
subject: androgens
subject: steroidogenesis
type: Text
identifier URI: http://hdl.handle.net/2429/89902