Cardiorespiratory Fitness as a Moderator of Sleep-Related Associations with Hippocampal Volume and Cognition
department or school: Medicine, Faculty of
department or school: Non UBC
department or school: Occupational Science and Occupational Therapy, Department of
department or school: Physical Therapy, Department of
data provider: DSpace
identifier citation: Brain Sciences 12 (10): 1360 (2022)
contributor: Djavad Mowafaghian Centre for Brain Health
contributor: Centre for Hip Health and Mobility
creator: Alfini, Alfonso J.
creator: Won, Junyeon
creator: Weiss, Lauren R.
creator: Nyhuis, Casandra C.
creator: Zipunnikov, Vadim
creator: Spira, Adam P.
creator: Liu-Ambrose, Teresa
creator: Shackman, Alexander J.
creator: Smith, J. Carson
issued: 2024-12-17T17:23:11Z
issued: 2022-10-07
description: The objective of this study was to understand the associations of sleep and cardiorespiratory fitness with hippocampal volume and global cognition among older adults (n = 30, age = 65.8 years, female = 73.3%). Wrist actigraphy provided objective measures of nighttime sleep including sleep duration, average wake bout length (WBL; sleep disturbance), and wake-to-sleep transition probability (WTSP; sleep consolidation). Cardiorespiratory fitness was quantified via cycle exercise using a modified heart rate recovery approach. Magnetic resonance imaging was used to determine hippocampal volume and the Mini-Mental State Examination was used to assess global cognition. Fitness moderated associations of sleep with hippocampal volume and cognitive performance, whereby the association of WBL—an index of poor sleep—with hippocampal atrophy was stronger among less-fit individuals, and the association of sleep duration with cognitive performance was stronger among more-fit individuals. Across the fitness levels, a longer WBL was associated with lower cognitive performance, and a higher WTSP—an index of more consolidated sleep—was associated with greater hippocampal volume. Sleep and fitness were unrelated to the volume of an amygdala control region, suggesting a degree of neuroanatomical specificity. In conclusion, higher cardiorespiratory fitness may attenuate sleep disturbance-related hippocampal atrophy and magnify the cognitive benefits of good sleep. Prospective studies are needed to confirm these findings.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/89897
note: Citation: Alfini, A.J.; Won, J.; Weiss,L.R.; Nyhuis, C.C.; Zipunnikov, V.;Spira, A.P.; Liu-Ambrose, T.;Shackman, A.J.; Smith, J.C.Cardiorespiratory Fitness as aModerator of Sleep-RelatedAssociations with HippocampalVolume and Cognition. Brain Sci.2022, 12, 1360. https://doi.org/10.3390/brainsci12101360Academic Editor: Luigi De GennaroReceived: 12 August 2022Accepted: 3 October 2022Published: 7 October 2022Publisher’s Note: MDPI stays neutralwith regard to jurisdictional claims inpublished maps and institutional affil-iations.Copyright: © 2022 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).brainsciencesArticleCardiorespiratory Fitness as a Moderator of Sleep-RelatedAssociations with Hippocampal Volume and CognitionAlfonso J. Alfini 1, Junyeon Won 2, Lauren R. Weiss 2,3, Casandra C. Nyhuis 4 , Vadim Zipunnikov 5,Adam P. Spira 6,7,8, Teresa Liu-Ambrose 9,10,11, Alexander J. Shackman 3,12,13 and J. Carson Smith 2,3,13,*1 National Center on Sleep Disorders Research, Division of Lung Diseases, National Heart, Lung, and BloodInstitute, NIH, Bethesda, MD 20817, USA2 Department of Kinesiology, University of Maryland School of Public Health, College Park, MD 20742, USA3 Neuroscience and Cognitive Science Program, University of Maryland, College Park, MD 20742, USA4 Department of Public Health Sciences, Pennsylvania State University College of Medicine,Hershey, PA 17033, USA5 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA6 Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA7 Center on Aging and Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA8 Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine,Baltimore, MD 21205, USA9 Department o…
has type: Article
is shown at: 10.14288/1.0447523
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/brainsci12101360
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
scholar level: Researcher
subject: sleep
subject: actigraphy
subject: brain volume
subject: heart rate recovery
subject: aging
type: Text
identifier URI: http://hdl.handle.net/2429/89897