Advanced Biomaterials for Lacrimal Tissue Engineering: A Review
department or school: Medicine, Faculty of
department or school: Non UBC
department or school: Medicine, Department of
data provider: DSpace
identifier citation: Materials 17 (22): 5425 (2024)
creator: Wu, Kevin Y.
creator: Dave, Archan
creator: Daigle, Patrick
creator: Tran, Simon D.
issued: 2024-11-29T19:50:52Z
issued: 2024-11-06
description: The lacrimal gland (LG) is vital for ocular health, producing tears that lubricate and protect the eye. Dysfunction of the LG leads to aqueous-deficient dry eye disease (DED), significantly impacting quality of life. Current treatments mainly address symptoms rather than the underlying LG dysfunction, highlighting the need for regenerative therapies. Tissue engineering offers a promising solution, with biomaterials playing crucial roles in scaffolding and supporting cell growth for LG regeneration. This review focuses on recent advances in biomaterials used for tissue engineering of the lacrimal gland. We discuss both natural and synthetic biomaterials that mimic the extracellular matrix and provide structural support for cell proliferation and differentiation. Natural biomaterials, such as Matrigel, decellularized extracellular matrices, chitosan, silk fibroin hydrogels, and human amniotic membrane are evaluated for their biocompatibility and ability to support lacrimal gland cells. Synthetic biomaterials, like polyethersulfone, polyesters, and biodegradable polymers (PLLA and PLGA), are assessed for their mechanical properties and potential to create scaffolds that replicate the complex architecture of the LG. We also explore the integration of growth factors and stem cells with these biomaterials to enhance tissue regeneration. Challenges such as achieving proper vascularization, innervation, and long-term functionality of engineered tissues are discussed. Advances in 3D bioprinting and scaffold fabrication techniques are highlighted as promising avenues to overcome current limitations.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/89751
note: Citation: Wu, K.Y.; Dave, A.; Daigle,P.; Tran, S.D. Advanced Biomaterialsfor Lacrimal Tissue Engineering: AReview. Materials 2024, 17, 5425.https://doi.org/10.3390/ma17225425Academic Editor: Javier GilReceived: 30 September 2024Revised: 31 October 2024Accepted: 31 October 2024Published: 6 November 2024Copyright: © 2024 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).ReviewAdvanced Biomaterials for Lacrimal Tissue Engineering:A ReviewKevin Y. Wu 1 , Archan Dave 2, Patrick Daigle 1 and Simon D. Tran 3,*1 Department of Surgery, Division of Ophthalmology, University of Sherbrooke, Sherbrooke, QC J1G 2E8,Canada; yang.wu@usherbrooke.ca (K.Y.W.)2 Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada3 Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC H3A 1G1, Canada* Correspondence: simon.tran@mcgill.caAbstract: The lacrimal gland (LG) is vital for ocular health, producing tears that lubricate and protect theeye. Dysfunction of the LG leads to aqueous-deficient dry eye disease (DED), significantly impactingquality of life. Current treatments mainly address symptoms rather than the underlying LG dysfunction,highlighting the need for regenerative therapies. Tissue engineering offers a promising solution, withbiomaterials playing crucial roles in scaffolding and supporting cell growth for LG regeneration. Thisreview focuses on recent advances in biomaterials used for tissue engineering of the lacrimal gland.We discuss both natural and synthetic biomaterials that mimic the extracellular matrix and providestructural support for cell proliferation and differentiation. Natural biomaterials, such as Matrigel, de-cellularized extracellular matrices, chitosan, silk fibroin hydrogels, and human amniotic membrane areevaluated for their biocompa…
has type: Article
is shown at: 10.14288/1.0447369
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/ma17225425
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
subject: biomaterials
subject: tissue engineering
subject: lacrimal gland
subject: dry eye disease
subject: natural and synthetic biomaterials
subject: 3D bioprinting
subject: regenerative medicine
type: Text
identifier URI: http://hdl.handle.net/2429/89751