Metabolomic Profiling Reveals That Exercise Lowers Biomarkers of Cardiac Dysfunction in Rats with Type 2 Diabetes
department or school: Medicine, Faculty of
department or school: Non UBC
department or school: Anesthesiology, Pharmacology and Therapeutics, Department of
data provider: DSpace
identifier citation: Antioxidants 13 (10): 1167 (2024)
creator: Wang, Tutu
creator: Ning, Miaomiao
creator: Mo, Yurou
creator: Tian, Xinyu
creator: Fu, Yu
creator: Laher, Ismail
creator: Li, Shunchang
issued: 2024-10-25T19:13:53Z
issued: 2024-09-26
description: The increasing prevalence of type 2 diabetes mellitus (T2DM) leads to significant global health challenges, including cardiac structural and functional deficits, which in severe cases can progress to heart failure that can further strain healthcare resources. Aerobic exercise can ameliorate cardiac dysfunction in individuals with diabetes, although a comprehensive understanding of its underlying mechanisms remains elusive. This study utilizes untargeted metabolomics to reveal aerobic-exercise-activated metabolic biomarkers in the cardiac tissues of Sprague Dawley rats with T2DM. Metabolomics analysis revealed that diabetes altered 1029 myocardial metabolites, while aerobic exercise reversed 208 of these metabolites, of which 112 were upregulated and 96 downregulated. Pathway topology analysis suggested that these metabolites predominantly contributed to purine metabolism and arginine biosynthesis. Furthermore, receiver operating characteristic curve analysis identified 10 potential biomarkers, including xanthine, hypoxanthine, inosine, dGMP, l-glutamic acid, l-arginine, l-tryptophan, (R)-3-hydroxybutyric acid, riboflavin, and glucolepidiin. Finally, data from Pearson correlation analysis indicated that some metabolic biomarkers strongly correlated with cardiac function. Our data suggest that certain metabolic biomarkers play an important role in ameliorating diabetes-related cardiac dysfunction by aerobic exercise.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/89539
note: Citation: Wang, T.; Ning, M.; Mo, Y.;Tian, X.; Fu, Y.; Laher, I.; Li, S.Metabolomic Profiling Reveals ThatExercise Lowers Biomarkers ofCardiac Dysfunction in Rats withType 2 Diabetes. Antioxidants 2024, 13,1167. https://doi.org/10.3390/antiox13101167Academic Editor: AlessandraNapolitanoReceived: 2 August 2024Revised: 5 September 2024Accepted: 16 September 2024Published: 26 September 2024Copyright: © 2024 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).antioxidantsArticleMetabolomic Profiling Reveals That Exercise Lowers Biomarkersof Cardiac Dysfunction in Rats with Type 2 DiabetesTutu Wang 1, Miaomiao Ning 1, Yurou Mo 1, Xinyu Tian 1, Yu Fu 1, Ismail Laher 2 and Shunchang Li 1,*1 Institute of Sports Medicine and Health, Chengdu Sport University, Chengdu 610041, China;wtt0306@126.com (T.W.); 15662088661@163.com (M.N.); 18508189746@163.com (Y.M.);t1138790522@163.com (X.T.); flytogether0909@163.com (Y.F.)2 Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of BritishColumbia, Vancouver, BC V6T 1Z3, Canada; ismail.laher@ubc.ca* Correspondence: lishunchang@cdsu.edu.cnAbstract: The increasing prevalence of type 2 diabetes mellitus (T2DM) leads to significant globalhealth challenges, including cardiac structural and functional deficits, which in severe cases canprogress to heart failure that can further strain healthcare resources. Aerobic exercise can amelioratecardiac dysfunction in individuals with diabetes, although a comprehensive understanding of itsunderlying mechanisms remains elusive. This study utilizes untargeted metabolomics to revealaerobic-exercise-activated metabolic biomarkers in the cardiac tissues of Sprague Dawley rats withT2DM. Metabolomics analysis revealed that diabetes altered 1029 myocardial metabolites, while aero-bic exercise reve…
has type: Article
is shown at: 10.14288/1.0447141
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/antiox13101167
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
scholar level: Researcher
subject: type 2 diabetes
subject: cardiac function
subject: aerobic exercise
subject: metabolomics
type: Text
identifier URI: http://hdl.handle.net/2429/89539