Vitamin D in Melanoma: Potential Role of Cytochrome P450 Enzymes
department or school: Medicine, Faculty of
department or school: Non UBC
data provider: DSpace
identifier citation: Life 14 (4): 510 (2024)
contributor: Therapeutics Initiative (University of British Columbia)
creator: Ben-Eltriki, Mohamed
creator: Gayle, Erysa J.
creator: Paras, Jhoanne M.
creator: Nyame-Addo, Louisa
creator: Chhabra, Manik
creator: Deb, Subrata
issued: 2024-05-22T14:54:00Z
issued: 2024-04-15
description: Vitamin D is a promising anticancer agent for the prevention and treatment of several cancers, including melanoma. Low 25-hydroxyvitamin D levels, a routinely used marker for vitamin D, have been suggested as one of the factors in the development and progression of melanoma. The parent vitamin D needs activation by cytochrome P450 (CYP) enzymes to exert its actions via the vitamin D receptor (VDR). This review discusses the role of vitamin D in melanoma and how CYP-mediated metabolism can potentially affect the actions of vitamin D. Through interacting with the retinoid X receptor, VDR signaling leads to anti-inflammatory, antioxidative, and anticancer actions. Calcitriol, the dihydroxylated form of vitamin D₃, is the most active and potent ligand of VDR. CYP27A1, CYP27B1, and CYP2R1 are involved in the activation of vitamin D, whereas CYP24A1 and CYP3A4 are responsible for the degradation of the active vitamin D. CYP24A1, the primary catabolic enzyme of calcitriol, is overexpressed in melanoma tissues and cells. Several drug classes and natural health products can modulate vitamin D-related CYP enzymes and eventually cause lower levels of vitamin D and its active metabolites in tissues. Although the role of vitamin D in the development of melanoma is yet to be fully elucidated, it has been proposed that melanoma prevention may be significantly aided by increased vitamin D signaling. Furthermore, selective targeting of the catabolic enzymes responsible for vitamin D degradation could be a plausible strategy in melanoma therapy. Vitamin D signaling can be improved by utilizing dietary supplements or by modulating CYP metabolism. A positive association exists between the intake of vitamin D supplements and improved prognosis for melanoma patients. Further investigation is required to determine the function of vitamin D supplementation and specific enzyme targeting in the prevention of melanoma.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/88345
note: Citation: Ben-Eltriki, M.; Gayle, E.J.;Paras, J.M.; Nyame-Addo, L.;Chhabra, M.; Deb, S. Vitamin D inMelanoma: Potential Role ofCytochrome P450 Enzymes. Life 2024,14, 510. https://doi.org/10.3390/life14040510Academic Editor: Zhiwei HuReceived: 25 February 2024Revised: 1 April 2024Accepted: 9 April 2024Published: 15 April 2024Copyright: © 2024 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).lifeReviewVitamin D in Melanoma: Potential Role of CytochromeP450 EnzymesMohamed Ben-Eltriki 1,2,* , Erysa J. Gayle 3 , Jhoanne M. Paras 3, Louisa Nyame-Addo 3, Manik Chhabra 1and Subrata Deb 4,*1 Clinical Pharmacology Lab, Department of Pharmacology and Therapeutics, Max Rady College of Medicine,University of Manitoba, Winnipeg, MB R3E 0T6, Canada2 Cochrane Hypertension Review Group, Therapeutic Initiative, University of British Columbia,Vancouver, BC V6T 1Z3, Canada3 College of Biomedical Sciences, Larkin University, Miami, FL 33169, USA; egayle@myularkin.org (E.J.G.);jparas@myularkin.org (J.M.P.)4 Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL 33169, USA* Correspondence: mbeneltriki@alumni.ubc.ca (M.B.-E.); sdeb@alumni.ubc.ca (S.D.);Tel.: +1-780-695-6692 (M.B.-E.); +1-224-310-7870 (S.D.)Abstract: Vitamin D is a promising anticancer agent for the prevention and treatment of severalcancers, including melanoma. Low 25-hydroxyvitamin D levels, a routinely used marker for vitaminD, have been suggested as one of the factors in the development and progression of melanoma.The parent vitamin D needs activation by cytochrome P450 (CYP) enzymes to exert its actions viathe vitamin D receptor (VDR). This review discusses the role of vitamin D in melanoma and howCYP-mediated metabolism can potentially affect the actions of vitamin D. Through interacting withthe retinoid X rec…
has type: Article
is shown at: 10.14288/1.0443749
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/life14040510
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
scholar level: Researcher
subject: vitamin D
subject: melanoma
subject: cytochrome P450
subject: therapeutic prevention
subject: dermal expression
subject: anticancer effects
subject: supplementation
type: Text
identifier URI: http://hdl.handle.net/2429/88345