Epidemiology, Clinical, and Microbiological Characteristics of Multidrug-Resistant Gram-Negative Bacteremia in Qatar
department or school: Medicine, Faculty of
department or school: Non UBC
data provider: DSpace
identifier citation: Antibiotics 13 (4): 320 (2024)
creator: Abdel Hadi, Hamad
creator: Dargham, Soha R.
creator: Eltayeb, Faiha
creator: Ali, Mohamed O. K.
creator: Suliman, Jinan
creator: Ahmed, Shiema Abdalla M.
creator: Omrani, Ali S.
creator: Ibrahim, Emad Bashir
creator: Chen, Yuzhou
creator: Tsui, Clement K. M.
creator: Skariah, Sini
creator: Sultan, Ali
issued: 2024-05-13T14:53:52Z
issued: 2024-03-31
description: Antimicrobial resistance is a global healthcare threat with significant clinical and economic consequences peaking at secondary and tertiary care hospitals where multidrug-resistant Gram-negative bacteria (MDR GNB) lead to poor outcomes. A prospective study was conducted between January and December 2019 for all invasive bloodstream infections (BSIs) secondary to MDR GNB in Qatar identified during routine microbiological service to examine their clinical, microbiological, and genomic characteristics. Out of 3238 episodes of GNB BSIs, the prevalence of MDR GNB was 13% (429/3238). The predominant MDR pathogens were Escherichia coli (62.7%), Klebsiella pneumoniae (20.4%), Salmonella species (6.6%), and Pseudomonas aeruginosa (5.3%), while out of 245 clinically evaluated patients, the majority were adult males, with the elderly constituting almost one-third of the cohort and with highest observed risk for prolonged hospital stays. The risk factors identified included multiple comorbidities, recent healthcare contact, previous antimicrobial therapy, and admission to critical care. The in-hospital mortality rate was recorded at 25.7%, associated with multiple comorbidities, admission to critical care, and the acquisition of MDR Pseudomonas aeruginosa. Resistant pathogens demonstrated high levels of antimicrobial resistance but noticeable susceptibility to amikacin and carbapenems. Genomic analysis revealed that Escherichia coli ST131 and Salmonella enterica ST1 were the predominant clones not observed with other pathogens.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/88274
note: Citation: Abdel Hadi, H.; Dargham,S.R.; Eltayeb, F.; Ali, M.O.K.; Suliman,J.; Ahmed, S.A.M.; Omrani, A.S.;Ibrahim, E.B.; Chen, Y.; Tsui, C.K.M.;et al. Epidemiology, Clinical, andMicrobiological Characteristics ofMultidrug-Resistant Gram-NegativeBacteremia in Qatar. Antibiotics 2024,13, 320. https://doi.org/10.3390/antibiotics13040320Academic Editor: Jamie WagnerReceived: 28 February 2024Revised: 25 March 2024Accepted: 26 March 2024Published: 31 March 2024Copyright: © 2024 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).antibioticsArticleEpidemiology, Clinical, and Microbiological Characteristics ofMultidrug-Resistant Gram-Negative Bacteremia in QatarHamad Abdel Hadi 1,2,* , Soha R. Dargham 3, Faiha Eltayeb 4, Mohamed O. K. Ali 5, Jinan Suliman 6,Shiema Abdalla M. Ahmed 1, Ali S. Omrani 1,2 , Emad Bashir Ibrahim 4,7, Yuzhou Chen 8,Clement K. M. Tsui 8,9,10, Sini Skariah 11 and Ali Sultan 111 Communicable Diseases Centre, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar;sahmed84@hamad.qa (S.A.M.A.); aomrani@hamad.qa (A.S.O.)2 College of Medicine, Qatar University, Doha P.O. Box 2713, Qatar3 Department of Medical Education, Weill Cornell Medicine, Qatar Foundation, Doha P.O. Box 24144, Qatar;srd2003@qatar-med.cornell.edu4 Division of Microbiology, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation,Doha P.O. Box 3050, Qatar; feltayeb1@hamad.qa (F.E.); eelmagboul@hamad.qa (E.B.I.)5 Department of Internal Medicine, University Health Truman Medical Centre, Kansas City, MO 64108, USA;mabm4@umsyste.edu6 Department of Community Medicine, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar;jsuliman@hamad.qa7 Biomedical Research Centre, Qatar University, Doha P.O. Box 2713, Qatar8 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapo…
has type: Article
is shown at: 10.14288/1.0443083
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/antibiotics13040320
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
scholar level: Researcher
subject: antimicrobial resistance
subject: Gram-negative bacteria
subject: multidrug resistance
subject: bacteremia
subject: bloodstream infection
subject: Qatar
type: Text
identifier URI: http://hdl.handle.net/2429/88274