Is there a Difference in the Immune Response, Efficacy, Effectiveness and Safety of Seasonal Influenza Vaccine in Males and Females? : A Systematic Review
department or school: Medicine, Faculty of
department or school: Non UBC
department or school: Pediatrics, Department of
data provider: DSpace
identifier citation: Tadount F, Doyon-Plourde P, Rafferty E, et al. Is there a Difference in the Immune Response, Efficacy, Effectiveness and Safety of Seasonal Influenza Vaccine in Males and Females? – A Systematic Review. Vaccine 2020; 38: 444-459.
contributor: Children's Hospital (Vancouver, B.C.). Vaccine Evaluation Center
contributor: Children's Hospital (Vancouver, B.C.). Research Institute
contributor: University of British Columbia. Division of Infectious Diseases
creator: Tadount, Fazia
creator: Doyon-Plourde, Pamela
creator: Rafferty, Ellen
creator: MacDonald, Shannon
creator: Sadarangani, Manish
creator: Quach, Caroline
issued: 2024-04-10T18:36:39Z
issued: 2020-01-06
description: Introduction: Seasonal influenza is an important cause of morbidity and mortality, despite being vaccine-preventable. Sex factors (genes and hormones) seem to impact individuals’ susceptibility to infectious diseases and their response to vaccination. However, most vaccine studies do not explicitly assess sex differences in vaccine response, but rather adjust for sex. Methods: We conducted a systematic review to analyze immunogenicity, efficacy, effectiveness and/or safety of seasonal influenza vaccine data stratified by sex. We searched PubMed, EMBASE, CINAHL, Web of Science and clinicaltrials.gov for observational studies and phase III/IV trials from January 1990 to June 2018, published in English or French. Two reviewers independently screened all references, then proceeded to data extraction and quality assessment using the Cochrane tools (RoB and ROBINS-I) on included studies. Results: Of the 5,745 citations retrieved, 46 studies were included in the SR. Overall, 18 studies assessed immunogenicity, 1 estimated efficacy, 6 measured effectiveness and 25 evaluated safety of seasonal influenza vaccine in females and males (four studies reported on two sex-stratified outcomes concomitantly). Conclusion: No clear conclusion could be drawn regarding the effect of sex on the immunogenicity and effectiveness of seasonal influenza vaccine, but higher rates of adverse events following immunization (AEFIs) were reported in females. The heterogeneity of data and studies’ low quality prevented us from conducting a meta-analysis. There is a need to emphasize on the appropriate use of the terms sex and gender in biomedical research. Evidence of higher quality is needed to better understand sex differences in response to influenza vaccine.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/87736
note: 1 "This is the peer reviewed version of the following article: Tadount F, Doyon-Plourde P, Rafferty E, et al. Is there a Difference in the Immune Response, Efficacy, Effectiveness and Safety of Seasonal Influenza Vaccine in Males and Females? – A Systematic Review. Vaccine 2020; 38., which has been published in final form at 10.1016/j.vaccine.2019.10.091. This article may be used for non-commercial purposes in accordance with Elsevier Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Elsevier or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Elsevier’s version of record on Science Direct and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Science Direct must be prohibited.1 Is there a Difference in the Immune Response, Efficacy, 2 Effectiveness and Safety of Seasonal Influenza Vaccine in 3 Males and Females? – A Systematic Review 4 5 Fazia Tadount, M.Sc. 1,2 6 Pamela Doyon-Plourde, B.Sc. 1,2 7 Ellen Rafferty3 8 Shannon MacDonald3 9 Manish Sadarangani4,5 10 Caroline Quach, MD, M.Sc., FRCPC 1,2,6,7 11 12 1Department of Microbiology, Infectious Diseases, and Immunology, Faculty of Medicine, 13 University of Montreal (QC) Canada 14 2Research Institute – CHU Sainte Justine, Montreal (QC) Canada 15 3Faculty of Nursing, University of Alberta, Edmonton (AB) Canada 16 4Vaccine Evaluation Center, BC Children’s Hospital Research Institute, Vancouver (BC) Canada 17 5Division of Infectious Diseases, Department of Pediatrics, University of British Columbia, 18 Vancouver (BC) Canada 19 6Department of Pediatric Laboratory Medicine, CHU Sainte-Justine, Montreal (QC) Canada 20 7Infection Prevention & Control, CHU Sainte-Justine, Montreal (QC) Canada 21 Corresponding…
has type: Article
has type: Postprint
is shown at: 10.14288/1.0441292
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Elsevier
publisher DOI: 10.1016/j.vaccine.2019.10.091
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Faculty
scholar level: Researcher
subject: Influenza
subject: Vaccines
subject: Sex differences
subject: Immunity
subject: Safety
type: Text
identifier URI: http://hdl.handle.net/2429/87736