Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections
department or school: Medicine, Faculty of
department or school: Non UBC
department or school: Biomedical Engineering, School of
department or school: Surgery, Department of
data provider: DSpace
identifier citation: Viruses 13 (11): 2239 (2021)
contributor: Children's Hospital (Vancouver, B.C.). Research Institute
creator: Kennedy, Allison E.
creator: Cook, Laura
creator: Breznik, Jessica A.
creator: Cowbrough, Braeden
creator: Wallace, Jessica G.
creator: Huynh, Angela
creator: Smith, James W.
creator: Son, Kiho
creator: Stacey, Hannah
creator: Ang, Jann
creator: McGeer, Allison
creator: Coleman, Brenda L.
creator: Larché, Maggie
creator: Larché, Mark
creator: Hambly, Nathan
creator: Nair, Parameswaran
creator: Ask, Kjetil
creator: Miller, Matthew S.
creator: Bramson, Jonathan
creator: Levings, Megan K.
creator: Nazy, Ishac
creator: Svenningsen, Sarah
creator: Mukherjee, Manali
creator: Bowdish, Dawn M. E.
issued: 2021-11-29T19:26:52Z
issued: 2021-11-08
description: Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular immune phenotype and function in individuals who had recovered from mild SARS-CoV-2 infections (n = 22), compared to those that had recovered from other mild respiratory infections (n = 11). Individuals who had experienced mild SARS-CoV-2 infections had elevated levels of C-reactive protein 1–3 months after symptom onset, and changes in phenotype and function of circulating T-cells that were not apparent in individuals 6–9 months post-symptom onset. Markers of monocyte activation, and expression of adherence and chemokine receptors indicative of altered migratory capacity, were also higher at 1–3 months post-infection in individuals who had mild SARS-CoV-2, but these were no longer elevated by 6–9 months post-infection. Perhaps most surprisingly, significantly more T-cells could be activated by polyclonal stimulation in individuals who had recently experienced a mild SARS-CoV-2, infection compared to individuals with other recent respiratory infections. These data are indicative of prolonged immune activation and systemic inflammation that persists for at least three months after mild or asymptomatic SARS-CoV-2 infections.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/80285
note: virusesArticleLasting Changes to Circulating Leukocytes in People with MildSARS-CoV-2 InfectionsAllison E. Kennedy 1,2,3,† , Laura Cook 4,5,† , Jessica A. Breznik 1,2,3 , Braeden Cowbrough 1,2,3,Jessica G. Wallace 1,2,3, Angela Huynh 3, James W. Smith 3, Kiho Son 3,6 , Hannah Stacey 1,2,7, Jann Ang 1,2,7,Allison McGeer 8,9, Brenda L. Coleman 8,9 , Maggie Larché 3, Mark Larché 3, Nathan Hambly 3,6,Parameswaran Nair 3,6, Kjetil Ask 3,6, Matthew S. Miller 1,2,7 , Jonathan Bramson 1,3, Megan K. Levings 4,10,11,Ishac Nazy 3,12, Sarah Svenningsen 3,6, Manali Mukherjee 3,6 and Dawn M. E. Bowdish 1,2,3,6,*Citation: Kennedy, A.E.; Cook, L.;Breznik, J.A.; Cowbrough, B.; Wallace,J.G.; Huynh, A.; Smith, J.W.; Son, K.;Stacey, H.; Ang, J.; et al. LastingChanges to Circulating Leukocytes inPeople with Mild SARS-CoV-2Infections. Viruses 2021, 13, 2239.https://doi.org/10.3390/v13112239Academic Editor: Andrew DavidsonReceived: 13 October 2021Accepted: 1 November 2021Published: 8 November 2021Publisher’s Note: MDPI stays neutralwith regard to jurisdictional claims inpublished maps and institutional affil-iations.Copyright: © 2021 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).1 McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8S 4K1, Canada;allkennedy@nosm.ca (A.E.K.); breznikj@mcmaster.ca (J.A.B.); cowbroub@mcmaster.ca (B.C.);wallacjg@mcmaster.ca (J.G.W.); staceyhd@mcmaster.ca (H.S.); ang.jann.catherine@gmail.com (J.A.);mmiller@mcmaster.ca (M.S.M.); bramson@mcmaster.ca (J.B.)2 Michael G. DeGroote Institute for Infectious Disease Research, McMaster University,Hamilton, ON L8S 4L8, Canada3 Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University,Hamilton, ON L8S 4K1, Canada; huynha8@mcmaster.ca (A.H.); smithjw@mcmaster.ca (J.W.S.);sonk@mcmaster.ca (K.S.); mlar…
has type: Article
is shown at: 10.14288/1.0404396
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/v13112239
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
scholar level: Researcher
subject: COVID-19
subject: SARS-CoV-2
subject: immunophenotype
subject: inflammation
subject: immune activation
type: Text
identifier URI: http://hdl.handle.net/2429/80285