A living WHO guideline on drugs for covid-19
department or school: Medicine, Faculty of
department or school: Non UBC
department or school: Emergency Medicine, Department of
department or school: Pediatrics, Department of
data provider: DSpace
identifier citation: Rochwerg, B., Siemieniuk, R. A., Agoritsas, T., Lamontagne, F., Askie, L., Lytvyn, L., Agarwal, A., Leo, Y., Macdonald, H., Zeng, L., Amin, W., Burhan, E., Bausch, F. J., Calfee, C. S., Cecconi, M., Chanda, D., Du, B., Geduld, H., Gee, P., . . . Vandvik, P. O. (2020). A living WHO guideline on drugs for covid-19. BMJ (Online), 370.
rights copyright: Authors
creator: Rochwerg, Bram
creator: Siemieniuk, Reed A. C.
creator: Agoritsas, Thomas
creator: Lamontagne, François
creator: Askie, Lisa
creator: Lytvyn, Lyubov
creator: Agarwal, Arnav
creator: Leo, Yee-Sin
creator: Macdonald, Helen
creator: Zeng, Linan
creator: Amin, Wagdy
creator: Burhan, Erlina
creator: Bausch, Frederique Jacquerioz
creator: Calfee, Carolyn S.
creator: Cecconi, Maurizio
creator: Chanda, Duncan
creator: Du, Bin
creator: Geduld, Heike
creator: Gee, Patrick
creator: Harley, Nerina
creator: Hashimi, Madiha
creator: Hunt, Beverly
creator: Kabra, Sushil K.
creator: Kanda, Seema
creator: Kawano-Dourado, Leticia
creator: Kim, Yae-Jean
creator: Kissoon, Niranjan
creator: Kwizera, Arthur
creator: Mahaka, Imelda
creator: Manai, Hela
creator: Mino, Greta
creator: Nsutebu, Emmanuel
creator: Pshenichnaya, Natalia
creator: Qadir, Nida
creator: Sabzwari, Saniya
creator: Sarin, Rohit
creator: Shankar-Hari, Manu
creator: Sharland, Michael
creator: Shen, Yinzhong
creator: Sri Ranganathan, Shalini
creator: Souza, Joao P.
creator: Stegemann, Miriam
creator: De Sutter, An
creator: Ugarte, Sebastian
creator: Venkatapuram, Sridhar
creator: Quoc Dat, Vu
creator: Vuyiseka, Dubula
creator: Wijewickrama, Ananda
creator: Maguire, Brittany
creator: Zeraatkar, Dena
creator: Bartoszko, Jessica J.
creator: Ge, Long
creator: Brignardello-Petersen, Romina
creator: Owen, Andrew
creator: Guyatt, Gordon H.
creator: Diaz, Janet
creator: Jacobs, Michael
creator: Vandvik, Per Olav
issued: 2021-06-22T21:22:18Z
issued: 2020-09-04
description: Clinical question What is the role of drug interventions in the treatment of patients with covid-19? New recommendation Increased attention on ivermectin as a potential treatment for covid-19 triggered this recommendation. The panel made a recommendation against ivermectin in patients with covid-19 regardless of disease severity, except in the context of a clinical trial. Prior recommendations (a) a strong recommendation against the use of hydroxychloroquine in patients with covid-19, regardless of disease severity; (b) a strong recommendation against the use of lopinavir-ritonavir in patients with covid-19, regardless of disease severity; (c) a strong recommendation for systemic corticosteroids in patients with severe and critical covid-19; (d) a conditional recommendation against systemic corticosteroids in patients with non-severe covid-19, and (e) a conditional recommendation against remdesivir in hospitalised patients with covid-19. How this guideline was created This living guideline is from the World Health Organization (WHO) and provides up to date covid-19 guidance to inform policy and practice worldwide. Magic Evidence Ecosystem Foundation (MAGIC) provided methodological support. A living systematic review with network analysis informed the recommendations. An international guideline development group (GDG) of content experts, clinicians, patients, an ethicist and methodologists produced recommendations following standards for trustworthy guideline development using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Understanding the new recommendation There is insufficient evidence to be clear to what extent, if any, ivermectin is helpful or harmful in treating covid-19. There was a large degree of uncertainty in the evidence about ivermectin on mortality, need for mechanical ventilation, need for hospital admission, time to clinical improvement, and other patient-important outcomes. There is potential for harm with an…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/78756
note: RAPID RECOMMENDATIONSA living WHO guideline on drugs for covid-19Bram Rochwerg, 1, 2, a, c Reed AC Siemieniuk, 1, 2, a, * Thomas Agoritsas, 1, 3, 4, *, b François Lamontagne, 5, *, bLisa Askie, 6 Lyubov Lytvyn, 1, * Arnav Agarwal, 7, * Yee-Sin Leo, 8, a, b, c Helen Macdonald, 9, * Linan Zeng, 1,* Wagdy Amin, 10, a, c Erlina Burhan, 11, a, c Frederique Jacquerioz Bausch, 12, a, c Carolyn S Calfee, 13, b, cMaurizio Cecconi, 14, a, b, c Duncan Chanda, 15, a, c Bin Du, 16, a, c Heike Geduld, 17, a, b, c Patrick Gee, 18, a, b, cNerina Harley, 19, c Madiha Hashimi, 20, a, c Beverly Hunt, 21, c Sushil K Kabra, 22, a, c Seema Kanda, 23, a, b, cLeticia Kawano-Dourado, 24, a, b, c Yae-Jean Kim, 25, a, b, c Niranjan Kissoon, 26, a, b, c Arthur Kwizera, 27, a, b, cImeldaMahaka, 28, a, cHelaManai, 29, a, b, cGretaMino, 30, a, c Emmanuel Nsutebu, 31, a, cNatalia Pshenichnaya, 32,a, cNida Qadir, 33, a, b, c Saniya Sabzwari, 34, a, c Rohit Sarin, 35, a, b, cManu Shankar-Hari, 36, cMichael Sharland, 37,a, c Yinzhong Shen, 38, a, b, c Shalini Sri Ranganathan, 39, a, c Joao P Souza, 40, a, c Miriam Stegemann, 41, c An DeSutter, 42, c Sebastian Ugarte, 43, a, c Sridhar Venkatapuram, 44, a, c Vu Quoc Dat, 45, a, c Dubula Vuyiseka, 46, a,c Ananda Wijewickrama, 47, a, c Brittany Maguire, 48, * Dena Zeraatkar, 1, * Jessica J Bartoszko, 1, * Long Ge, 1,49, * Romina Brignardello-Petersen, 1, * Andrew Owen, 50, * Gordon Guyatt, 1, 2, * Janet Diaz, 6, *, dMichael Jacobs, 51, a, c, d Per Olav Vandvik4, 52, *, dABSTRACTCLINICAL QUESTIONWhat is the role of drug interventions in the treatmentof patients with covid-19?NEW RECOMMENDATIONIncreased attention on ivermectin as a potentialtreatment for covid-19 triggered this recommendation.The panel made a recommendation againstivermectin in patients with covid-19 regardless ofdisease severity, except in the context of a clinicaltrial.PRIOR RECOMMENDATIONS(a) a strong recommendation against the use ofhydroxychloroquine in patients with covid-19,regardle…
has type: Article
is shown at: 10.14288/1.0398490
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: BMJ
publisher DOI: 10.1136/bmj.m3379
rights: Attribution-NonCommercial 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc/4.0/
scholar level: Faculty