Platelet-Rich Plasma Applications for Achilles Tendon Repair: A Bridge between Biology and Surgery
department or school: Medicine, Faculty of
department or school: Non UBC
data provider: DSpace
identifier citation: International Journal of Molecular Sciences 22 (2): 824 (2021)
contributor: University of British Columbia. Allan McGavin Sports Medicine Clinic
creator: Padilla, Sabino
creator: Sánchez, Mikel
creator: Vaquerizo, Victor
creator: Malanga, Gerard A.
creator: Fiz, Nicolás
creator: Azofra, Juan
creator: Rogers, Christopher J.
creator: Samitier, Gonzalo
creator: Sampson, Steven
creator: Seijas, Roberto
creator: Elorriaga, Ricardo
creator: Taunton, Jack E.
creator: Boehm, Frank
creator: Prado, Roberto
creator: Cugat, Ramón
creator: Anitua, Eduardo
issued: 2021-01-26T17:57:33Z
issued: 2021-01-15
description: Achilles tendon ruptures are very common tendon ruptures and their incidence is increasing in modern society, resulting in work incapacity and months off sport, which generate a need for accelerated and successful therapeutic repair strategy. Platelet-rich plasma (PRP) is emerging as adjuvant human blood-derived constructs to assist Achilles tendon rupture treatment. However, myriad PRP preparation methods in conjunction with poor standardization in the modalities of their applications impinge on the consistent effectiveness of clinical and structural outcomes regarding their therapeutic efficacy. The purpose of this review is to provide some light on the application of PRP for Achilles tendon ruptures. PRP has many characteristics that make it an attractive treatment. Elements such as the inclusion of leukocytes and erythrocytes within PRP, the absence of activation and activation ex vivo or in vivo, the modality of application, and the adjustment of PRP pH can influence the biology of the applied product and result in misleading therapeutic conclusions. The weakest points in demonstrating their consistent effectiveness are primarily the result of myriad PRP preparation methods and the poor standardization of modalities for their application. Selecting the right biological scaffold and applying it correctly to restitutio ad integrum of ruptured Achilles tendons remains a daunting and complex task.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/77179
note: International Journal of Molecular SciencesReviewPlatelet-Rich Plasma Applications for Achilles Tendon Repair:A Bridge between Biology and SurgerySabino Padilla 1,2,3,* , Mikel Sánchez 4,5 , Victor Vaquerizo 6 , Gerard A. Malanga 7,8,9 , Nicolás Fiz 4,5 ,Juan Azofra 4,5 , Christopher J. Rogers 10, Gonzalo Samitier 11,12,13 , Steven Sampson 14,15 ,Roberto Seijas 11,12,13 , Ricardo Elorriaga 16 , Jack Taunton 17, Frank Boehm 18, Roberto Prado 1,2,3 ,Ramón Cugat 11,12,13 and Eduardo Anitua 1,2,3,*Citation: Padilla, S.; Sánchez, M.;Vaquerizo, V.; Malanga, G.A.; Fiz, N.;Azofra, J.; Rogers, C.J.; Samitier, G.;Sampson, S.; Seijas, R.; et al.Platelet-Rich Plasma Applications forAchilles Tendon Repair: A Bridgebetween Biology and Surgery. Int. J.Mol. Sci. 2021, 22, 824. https://doi.org/10.3390/ijms22020824Received: 23 December 2020Accepted: 10 January 2021Published: 15 January 2021Publisher’s Note: MDPI stays neu-tral with regard to jurisdictional clai-ms in published maps and institutio-nal affiliations.Copyright: © 2021 by the authors. Li-censee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms and con-ditions of the Creative Commons At-tribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).1 Eduardo Anitua Foundation for Biomedical Research, Jacinto Quincoces, 39, 01007 Vitoria, Spain;roberto.prado@bti-implant.es2 BTI-Biotechnology Institute ImasD, Jacinto Quincoces, 39, 01007 Vitoria, Spain3 University Institute for Regenerative Medicine & Oral Implantology-UIRMI (UPV/EHU-Fundación EduardoAnitua), Jacinto Quincoces, 39, 01007 Vitoria, Spain4 Arthroscopic Surgery Unit, Hospital Vithas Vitoria, Beato Tomás de Zumarraga 10, 01008 Vitoria-Gasteiz,Spain; mikel.sanchez@ucatrauma.com (M.S.); nicolas.fiz@ucatrauma.com (N.F.);juan.azofra@ucatrauma.com (J.A.)5 Advanced Biological Therapy Unit, Hospital Vithas Vitoria, 01008 Vitoria-Gasteiz, Spain6 Department of Orthopaedic Surgery, Príncipe de Asturias University Hospital,…
has type: Article
is shown at: 10.14288/1.0395744
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/ijms22020824
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
scholar level: Researcher
subject: Achilles
subject: platelet-rich plasma
subject: PRGF
subject: tendon
type: Text
identifier URI: http://hdl.handle.net/2429/77179