Quadriceps Weakness and the Risk of Knee Cartilage Loss on Magnetic Resonance Imaging in a Population-Based Cohort with Knee Pain
department or school: Medicine, Faculty of
department or school: Non UBC
department or school: Medicine, Department of
department or school: Population and Public Health (SPPH), School of
data provider: DSpace
alternative: Weakness and MRI Knee Cartilage loss
identifier citation: Chin C, Sayre EC, Guermazi A, Nicolaou S, Esdaile JM, Kopec J, Thorne A, Singer J, Wong H, Cibere J. Quadriceps weakness and the risk of knee cartilage loss on MRI in a population-based cohort with knee pain. J Rheumatol. 2019 Feb;46(2):198-203.
creator: Chin, Carson
creator: Sayre, E. C.
creator: Guermazi, Ali
creator: Nicolaou, Savvas
creator: Esdaile, John
creator: Kopeć, Jacek A.
creator: Thorne, Anona
creator: Singer, Joel
creator: Wong, Hubert
creator: Cibere, Jolanda, 1962-
issued: 2020-01-10T23:07:11Z
issued: 2018-10-01
description: Objective. To determine whether baseline quadriceps weakness predicts cartilage loss on magnetic resonance imaging (MRI). Methods. Subjects aged 40-79 with knee pain (n=163) were recruited from a random population sample and examined for quadriceps weakness with manual isometric strength testing, using a 3-point scoring system (0=poor resistance, 1=moderate resistance, 2=full resistance), which was dichotomized as normal (grade 2) vs weak (grade 0/1). MRI of the more symptomatic knee was obtained at baseline and at mean of 3.3-years. Cartilage was graded 0-4 on MRI. Exponential regression analysis was used to evaluate whether quadriceps weakness was associated with whole knee cartilage loss and, in secondary analyses with compartment specific cartilage loss, adjusted for age, sex, body mass index, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain and baseline MRI cartilage score. Results. Of 163 subjects, 54% were female, mean age 57.7 years. Quadriceps weakness was seen in 11.9% of the subjects. Weakness was a predictor of whole knee cartilage loss (hazard ratio [HR] 3.48, 95% confidence interval [CI] 1.30-9.35). Quadriceps weakness was associated with cartilage loss in the medial tibiofemoral (TF) compartment (HR 4.60, 95% CI 1.25-17.02), while no significant association was found with lateral TF (HR 1.53, 95% CI 0.24-9.78) or patellofemoral compartment (HR 2.76, 95% CI 0.46-16.44). Conclusion. In this symptomatic, population-based cohort, quadriceps weakness predicted whole knee and medial TF cartilage loss after 3 years. This is the first study to show that a simple clinical examination of quadriceps strength can predict the risk of knee cartilage loss.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/73292
note: Quadriceps Weakness and MRI Knee Cartilage loss 1 Quadriceps Weakness and the Risk of Knee Cartilage Loss on Magnetic Resonance Imaging in a Population-Based Cohort with Knee Pain Carson Chin, Eric C. Sayre, Ali Guermazi, Savvas Nicolaou, John M. Esdaile, Jacek Kopec, Anona Thorne, Joel Singer, Hubert Wong, Jolanda Cibere ABSTRACT Objective. To determine whether baseline quadriceps weakness predicts cartilage loss on magnetic resonance imaging (MRI). Methods. Subjects aged 40-79 with knee pain (n=163) were recruited from a random population sample and examined for quadriceps weakness with manual isometric strength testing, using a 3-point scoring system (0=poor resistance, 1=moderate resistance, 2=full resistance), which was dichotomized as normal (grade 2) vs weak (grade 0/1). MRI of the more symptomatic knee was obtained at baseline and at mean of 3.3-years. Cartilage was graded 0-4 on MRI. Exponential regression analysis was used to evaluate whether quadriceps weakness was associated with whole knee cartilage loss and, in secondary analyses with compartment specific cartilage loss, adjusted for age, sex, body mass index, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain and baseline MRI cartilage score. Results. Of 163 subjects, 54% were female, mean age 57.7 years. Quadriceps weakness was seen in 11.9% of the subjects. Weakness was a predictor of whole knee cartilage loss (hazard ratio [HR] 3.48, 95% confidence interval [CI] 1.30-9.35). Quadriceps weakness was associated with cartilage loss in the medial tibiofemoral (TF) compartment (HR 4.60, 95% CI 1.25-17.02), Quadriceps Weakness and MRI Knee Cartilage loss 2 while no significant association was found with lateral TF (HR 1.53, 95% CI 0.24-9.78) or patellofemoral compartment (HR 2.76, 95% CI 0.46-16.44). Conclusion. In this symptomatic, population-based cohort, quadriceps weakness predicted whole knee and medial TF cartilage loss after 3 years. This is the first study to show that a simple …
has type: Article
has type: Postprint
is shown at: 10.14288/1.0388269
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher DOI: 10.3899/jrheum.170875
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Faculty
subject: Osteoarthritis
subject: Cartilage
subject: Magnetic resonance imaging
subject: Quadriceps muscle weakness
subject: Cohort
type: Text
identifier URI: http://hdl.handle.net/2429/73292