Blood Mitochondrial DNA Content in HIV-Exposed Uninfected Children with Autism Spectrum Disorder
department or school: Medicine, Faculty of
department or school: Other UBC
department or school: Non UBC
department or school: Medical Genetics, Department of
department or school: Pathology and Laboratory Medicine, Department of
department or school: Pediatrics, Department of
department or school: Population and Public Health (SPPH), School of
data provider: DSpace
identifier citation: Viruses 10 (2): 77 (2018)
contributor: University of British Columbia. Centre for Blood Research
creator: Budd, Matthew A.
creator: Calli, Kristina
creator: Samson, Lindy
creator: Bowes, Jennifer
creator: Hsieh, Anthony Y. Y.
creator: Forbes, John C.
creator: Bitnun, Ari
creator: Singer, Joel
creator: Kakkar, Fatima
creator: Alimenti, Ariane
creator: Maan, Evelyn J.
creator: Lewis, M. E. Suzanne
creator: Gentile, Carole
creator: Côté, Hélène C. F.
creator: Brophy, Jason C.
issued: 2019-07-04T15:56:01Z
issued: 2018-02-11
description: Long-term outcomes of perinatal exposure to maternal antiretroviral therapy in HIV-exposed uninfected (HEU) children are unknown. However, both HIV antiretroviral therapy and autism spectrum disorder (ASD) have been associated with mitochondrial alterations. Leukocyte mitochondrial DNA (mtDNA) content can serve as a marker for mitochondrial dysfunction. In this cross-sectional, nested case-control study, HEU children with ASD were matched approximately 1:3 on age, sex, and ethnicity to HEU children without ASD, HIV-unexposed uninfected (HUU) controls, and HUU children with ASD. Leukocyte mtDNA content was measured using quantitative PCR. Among 299 HEU in this study, 14 (4.7%) were diagnosed with ASD, which is higher than the general population prevalence estimates. HEU children without ASD and HUU children with ASD had higher mtDNA content than HUU controls. HEU children with ASD had significantly higher mtDNA content than all other study groups. Our results suggest a clear association between elevated leukocyte mtDNA content and both HEU and ASD status. This may implicate mitochondrial dysfunction as a contributor to the high ASD prevalence observed in our cohort.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/70889
note: virusesArticleBlood Mitochondrial DNA Content in HIV-ExposedUninfected Children with Autism Spectrum DisorderMatthew A. Budd 1,2, Kristina Calli 3, Lindy Samson 4,5, Jennifer Bowes 5,Anthony Y. Y. Hsieh 1,2, John C. Forbes 6, Ari Bitnun 7, Joel Singer 8,9, Fatima Kakkar 10,Ariane Alimenti 6,11, Evelyn J. Maan 11,12, M. E. Suzanne Lewis 3, Carole Gentile 13,Hélène C.F. Côté 1,2,12,* and Jason C. Brophy 4,5 ID for the CIHR Team on Cellular Aging and HIVComorbidities in Women and Children (CARMA)1 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5,Canada; m.budd@alumni.ubc.ca (M.A.B.); anthony_y_hsieh@hotmail.com (A.Y.Y.H.)2 Centre for Blood Research, University of British Columbia, Vancouver, BC V6T 1Z3, Canada3 Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada;kcalli@mail.ubc.ca (K.C.); suzanne.lewis@ubc.ca (M.E.S.L.)4 Department of Pediatrics, University of Ottawa, Ottawa, ON K1H 8L1, Canada; Samson@cheo.on.ca (L.S.);JBrophy@cheo.on.ca (J.C.B.)5 Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada; jbowes@cheo.on.ca6 Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada;jcforbes@shaw.ca (J.C.F.); aalimenti@cw.bc.ca (A.A.)7 Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8,Canada; ari.bitnun@sickkids.ca8 CIHR Canadian HIV Trials Network, Vancouver, BC V6Z 1Y6, Canada; jsinger@hivnet.ubc.ca9 School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada10 Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada;fatima.kakkar@umontreal.ca11 Oak Tree Clinic, BC Women’s Hospital and Health Centre, Vancouver, BC V6H 3N1, Canada;emaan@cw.bc.ca12 Women’s Health Research Institute, Vancouver, BC V6H 3N1, Canada13 Department of Psychology, Children’s Hospital of Eastern Ontario, Otta…
has type: Article
is shown at: 10.14288/1.0379749
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/v10020077
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
subject: Antiretroviral therapy
subject: Genetics
subject: Neurodevelopment
subject: Prophylaxis
subject: Mitochondria
subject: HIV
subject: Pediatrics
type: Text
identifier URI: http://hdl.handle.net/2429/70889