Optimization of Iron Oxide Tracer Synthesis for Magnetic Particle Imaging
department or school: Other UBC
department or school: Non UBC
data provider: DSpace
identifier citation: Nanomaterials 8 (4): 180 (2018)
creator: Ziemian, Sabina
creator: Löwa, Norbert
creator: Kosch, Olaf
creator: Bajj, Daniel
creator: Wiekhorst, Frank
creator: Schütz, Gunnar
issued: 2019-06-27T17:11:30Z
issued: 2018-03-21
description: The optimization of iron oxide nanoparticles as tracers for magnetic particle imaging (MPI) alongside the development of data acquisition equipment and image reconstruction techniques is crucial for the required improvements in image resolution and sensitivity of MPI scanners. We present a large-scale water-based synthesis of multicore superparamagnetic iron oxide nanoparticles stabilized with dextran (MC-SPIONs). We also demonstrate the preparation of single core superparamagnetic iron oxide nanoparticles in organic media, subsequently coated with a poly(ethylene glycol) gallic acid polymer and phase transferred to water (SC-SPIONs). Our aim was to obtain long-term stable particles in aqueous media with high MPI performance. We found that the amplitude of the third harmonic measured by magnetic particle spectroscopy (MPS) at 10 mT is 2.3- and 5.8-fold higher than Resovist for the MC-SPIONs and SC-SPIONs, respectively, revealing excellent MPI potential as compared to other reported MPI tracer particle preparations. We show that the reconstructed MPI images of phantoms using optimized multicore and specifically single-core particles are superior to that of commercially available Resovist, which we utilize as a reference standard, as predicted by MPS.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/70854
note: nanomaterialsArticleOptimization of Iron Oxide Tracer Synthesis forMagnetic Particle ImagingSabina Ziemian 1,* ID , Norbert Löwa 2 ID , Olaf Kosch 2, Daniel Bajj 3, Frank Wiekhorst 2and Gunnar Schütz 11 MR and CT Contrast Media Research, Bayer AG, D-13353 Berlin, Germany; gunnar.schuetz@bayer.com2 Physikalisch-Technische Bundesanstalt, D-10587 Berlin, Germany; Norbert.Loewa@ptb.de (N.L.);Olaf.Kosch@ptb.de (O.K.); Frank.Wiekhorst@ptb.de (F.W.)3 University of British Columbia, Vancouver, BC V6T 1Z3, Canada; daniel.bajj@alumni.ubc.ca* Correspondence: sabina.ziemian@bayer.com; Tel.: +49-304-681-94232Received: 23 February 2018; Accepted: 19 March 2018; Published: 21 March 2018Abstract: The optimization of iron oxide nanoparticles as tracers for magnetic particle imaging(MPI) alongside the development of data acquisition equipment and image reconstructiontechniques is crucial for the required improvements in image resolution and sensitivity of MPIscanners. We present a large-scale water-based synthesis of multicore superparamagnetic iron oxidenanoparticles stabilized with dextran (MC-SPIONs). We also demonstrate the preparation of singlecore superparamagnetic iron oxide nanoparticles in organic media, subsequently coated with apoly(ethylene glycol) gallic acid polymer and phase transferred to water (SC-SPIONs). Our aim wasto obtain long-term stable particles in aqueous media with high MPI performance. We found thatthe amplitude of the third harmonic measured by magnetic particle spectroscopy (MPS) at 10 mT is2.3- and 5.8-fold higher than Resovist for the MC-SPIONs and SC-SPIONs, respectively, revealingexcellent MPI potential as compared to other reported MPI tracer particle preparations. We show thatthe reconstructed MPI images of phantoms using optimized multicore and specifically single-coreparticles are superior to that of commercially available Resovist, which we utilize as a referencestandard, as predicted by MPS.Keywords: magnetic particle imaging (MPI); magnetic pa…
has type: Article
is shown at: 10.14288/1.0379671
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/nano8040180
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
subject: Magnetic particle imaging (MPI)
subject: Magnetic particle spectroscopy (MPS)
subject: Iron oxide tracer
subject: Superparamagnetic nanoparticles
type: Text
identifier URI: http://hdl.handle.net/2429/70854