Biodegradable Cell-Seeded Nanofiber Scaffolds for Neural Repair
department or school: Applied Science, Faculty of
department or school: Electrical and Computer Engineering, Department of
data provider: DSpace
identifier citation: Polymers 3 (4): 1684-1733 (2011)
creator: Han, Dong
creator: Cheung, Karen C.
issued: 2019-04-04T16:48:38Z
issued: 2011-10-10
description: Central and peripheral neural injuries are traumatic and can lead to loss of motor and sensory function, chronic pain, and permanent disability. Strategies that bridge the site of injury and allow axonal regeneration promise to have a large impact on restoring quality of life for these patients. Engineered materials can be used to guide axonal growth. Specifically, nanofiber structures can mimic the natural extracellular matrix, and aligned nanofibers have been shown to direct neurite outgrowth and support axon regeneration. In addition, cell-seeded scaffolds can assist in the remyelination of the regenerating axons. The electrospinning process allows control over fiber diameter, alignment, porosity, and morphology. Biodegradable polymers have been electrospun and their use in tissue engineering has been demonstrated. This paper discusses aspects of electrospun biodegradable nanofibers for neural regeneration, how fiber alignment affects cell alignment, and how cell-seeded scaffolds can increase the effectiveness of such implants.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/69463
note: Polymers 2011, 3, 1684-1733; doi:10.3390/polym3041684 polymersISSN 2073-4360 www.mdpi.com/journal/polymers Review Biodegradable Cell-Seeded Nanofiber Scaffolds for Neural Repair Dong Han * and Karen C. Cheung Department of Electrical and Computer Engineering, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada; E-Mail: kcheung@ece.ubc.ca * Author to whom correspondence should be addressed; E-Mail: dhan@ece.ubc.ca; Tel.: +1-604-827-4114; Fax: +1-604-822-5949. Received: 24 August 2011; in revised form: 14 September 2011 / Accepted: 6 October 2011 / Published: 10 October 2011 Abstract: Central and peripheral neural injuries are traumatic and can lead to loss of motor and sensory function, chronic pain, and permanent disability. Strategies that bridge the site of injury and allow axonal regeneration promise to have a large impact on restoring quality of life for these patients. Engineered materials can be used to guide axonal growth. Specifically, nanofiber structures can mimic the natural extracellular matrix, and aligned nanofibers have been shown to direct neurite outgrowth and support axon regeneration. In addition, cell-seeded scaffolds can assist in the remyelination of the regenerating axons. The electrospinning process allows control over fiber diameter, alignment, porosity, and morphology. Biodegradable polymers have been electrospun and their use in tissue engineering has been demonstrated. This paper discusses aspects of electrospun biodegradable nanofibers for neural regeneration, how fiber alignment affects cell alignment, and how cell-seeded scaffolds can increase the effectiveness of such implants. Keywords: neural regeneration; electrospinning; nanotechnology; polymer; nanofibers; bioconduits; biomaterials; axonal guidance 1. Introduction The nervous system comprises the peripheral nervous system (PNS) and the central nervous system (CNS). The PNS obtains information from the environment and transports signals from and to the OPEN ACCESSPol…
has type: Article
is shown at: 10.14288/1.0377814
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/polym3041684
rights: CC BY 3.0
rights URI: https://creativecommons.org/licenses/by-nc-sa/3.0/
scholar level: Faculty
subject: Neural regeneration
subject: Electrospinning
subject: Nanotechnology
subject: Polymer
subject: Nanofibers
subject: Bioconduits
subject: Biomaterials
subject: Axonal guidance
type: Text
identifier URI: http://hdl.handle.net/2429/69463