Structural plasticity of the hippocampus in response to estrogens in female rodents
department or school: Arts, Faculty of
department or school: Medicine, Faculty of
department or school: Other UBC
department or school: Non UBC
department or school: Psychology, Department of
data provider: DSpace
identifier citation: Molecular Brain. 2019 Mar 18;12(1):22
contributor: University of British Columbia. Graduate Program in Neuroscience
contributor: Djavad Mowafaghian Centre for Brain Health
rights copyright: The Author(s).
creator: Sheppard, Paul A. S.
creator: Choleris, Elena
creator: Galea, Liisa A. M.
issued: 2019-03-18T17:41:58Z
issued: 2019-03-18
description: It is well established that estrogens affect neuroplasticity in a number of brain regions. In particular, estrogens modulate and mediate spine and synapse formation as well as neurogenesis in the hippocampal formation. In this review, we discuss current research exploring the effects of estrogens on dendritic spine plasticity and neurogenesis with a focus on the modulating factors of sex, age, and pregnancy. Hormone levels, including those of estrogens, fluctuate widely across the lifespan from early life to puberty, through adulthood and into old age, as well as with pregnancy and parturition. Dendritic spine formation and modulation are altered both by rapid (likely non-genomic) and classical (genomic) actions of estrogens and have been suggested to play a role in the effects of estrogens on learning and memory. Neurogenesis in the hippocampus is influenced by age, the estrous cycle, pregnancy, and parity in female rodents. Furthermore, sex differences exist in hippocampal cellular and molecular responses to estrogens and are briefly discussed throughout. Understanding how structural plasticity in the hippocampus is affected by estrogens and how these effects can influence function and be influenced by other factors, such as experience and sex, is critical and can inform future treatments in conditions involving the hippocampus.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/68907
note: REVIEW Open AccessStructural plasticity of the hippocampus inresponse to estrogens in female rodentsPaul A. S. Sheppard1, Elena Choleris2 and Liisa A. M. Galea1*AbstractIt is well established that estrogens affect neuroplasticity in a number of brain regions. In particular, estrogensmodulate and mediate spine and synapse formation as well as neurogenesis in the hippocampal formation. In thisreview, we discuss current research exploring the effects of estrogens on dendritic spine plasticity and neurogenesiswith a focus on the modulating factors of sex, age, and pregnancy. Hormone levels, including those of estrogens,fluctuate widely across the lifespan from early life to puberty, through adulthood and into old age, as well as withpregnancy and parturition. Dendritic spine formation and modulation are altered both by rapid (likely non-genomic)and classical (genomic) actions of estrogens and have been suggested to play a role in the effects of estrogens onlearning and memory. Neurogenesis in the hippocampus is influenced by age, the estrous cycle, pregnancy, and parityin female rodents. Furthermore, sex differences exist in hippocampal cellular and molecular responses to estrogens andare briefly discussed throughout. Understanding how structural plasticity in the hippocampus is affected by estrogensand how these effects can influence function and be influenced by other factors, such as experience and sex, is criticaland can inform future treatments in conditions involving the hippocampus.Keywords: Neurogenesis, dendritic spines, sex differences, memory, depression, stress, aging, pregnancy, parityIntroductionNumerous investigations in animals and humans havefound sex differences in brain and behaviour [1]. Whilethe underlying impetus of these differences is complexand multi-faceted, differences in sex steroid hormones,particularly estrogens, appear to be of clinical and ex-perimental importance [2]. The manifestation, occur-rence, and/or severity of brain disorders suc…
has type: Article
is shown at: 10.14288/1.0377129
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: BioMed Central
publisher DOI: 10.1186/s13041-019-0442-7
rights: Attribution 4.0 International (CC BY 4.0)
rights URI: http://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
subject: Neurogenesis
subject: dendritic spines
subject: sex differences
subject: memory
subject: depression
subject: stress
subject: aging
subject: pregnancy
subject: parity
type: Text
identifier URI: http://hdl.handle.net/2429/68907