Personalized approaches to mental health interventions : effectiveness of ketamine-assisted therapy for treatment-resistant psychological conditions
department or school: Arts and Social Sciences, Irving K. Barber Faculty of (Okanagan)
department or school: Psychology, Department of (Okanagan)
data provider: DSpace
degree campus: UBCO
creator: Gregoire, Nina Honor Dyson
issued: 2025-04-10T19:03:15Z
issued: 2025
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Mental illness remains a leading cause of disability, with treatment-resistant conditions presenting significant challenges to clinicians and patients alike. This research explores the baseline characteristics, early treatment outcomes, and patient experiences of individuals undergoing ketamine-assisted therapy for treatment-resistant psychological conditions. Study 1 utilized latent profile analysis (LPA) on patients seeking ketamine treatment to identify three personality profiles and four symptom clusters. Personality and symptom profiles were associated with many meaningful baseline differences between participants but were not associated with treatment outcomes; that is, ketamine-assisted therapy led to reductions in both depression and anxiety across the personality and symptom profiles. Trauma history, however, predicted greater improvements in both depression and anxiety following ketamine treatment. Study 2 examined patient-reported experiences, revealing high levels of satisfaction with the treatment but significant barriers related to financial cost, accessibility, and post-treatment support. Together, these findings highlight the importance of tailoring ketamine-assisted therapy protocols to individual characteristics, emphasizing trauma-informed care, and addressing systemic inequities to enhance the accessibility and efficacy of this emerging therapy. Future research should prioritize longitudinal studies and randomized controlled trials to further refine personalized approaches to ketamine-assisted therapy.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/90628
note: PERSONALIZED APPROACHES TO MENTAL HEALTH INTERVENTIONS: EFFECTIVENESS OF KETAMINE-ASSISTED THERAPY FOR TREATMENT-RESISTANT PSYCHOLOGICAL CONDITIONS by Nina Honor Dyson Gregoire B.Sc. (Hons), University of British Columbia, 2017 M.A., University of British Columbia, 2021 A DISSERTATION SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE COLLEGE OF GRADUATE STUDIES (Psychology) THE UNIVERSITY OF BRITISH COLUMBIA (Okanagan) April 2025 © Nina Honor Dyson Gregoire, 2025 ii The following individuals certify that they have read, and recommend to the College of Graduate Studies for acceptance, a dissertation entitled: PERSONALIZED APPROACHES TO MENTAL HEALTH INTERVENTIONS: EFFECTIVENESS OF KETAMINE-ASSISTED THERAPY FOR TREATMENT-RESISTANT PSYCHOLOGICAL CONDITIONS submitted by Nina Honor Dyson Gregoire in partial fulfillment of the requirements of the degree of Doctor of Philosophy Dr. Paul G. Davies, Irving K. Barber Faculty of Arts and Social Sciences Supervisor Dr. Harry Miller, Irving K. Barber Faculty of Arts and Social Sciences Supervisory Committee Member Dr. Susan Holtzman, Irving K. Barber Faculty of Arts and Social Sciences Supervisory Committee Member Dr. Sally Stewart, Faculty of Health and Social Development University Examiner Dr. David Creswell, Carnegie Mellon University External Examiner iii Abstract Mental illness remains a leading cause of disability, with treatment-resistant conditions presenting significant challenges to clinicians and patients alike. This research explores the baseline characteristics, early treatment outcomes, and patient experiences of individuals undergoing ketamine-assisted therapy for treatment-resistant psychological conditions. Study 1 utilized latent profile analysis (LPA) on patients seeking ketamine treatment to identify three personality profiles and four symptom clusters. Personality and symptom profiles were associated with many meaningful baseline differences between participa…
has type: Thesis/Dissertation
date issued: 2025-05
is shown at: 10.14288/1.0448342
language: eng
degree discipline: Psychology
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Davies, Paul G.
type: Text
identifier URI: http://hdl.handle.net/2429/90628