Examining the feasibility of prolonged ketone supplement drink consumption in adults living with type 2 diabetes
department or school: Health and Social Development, Faculty of (Okanagan)
department or school: Health and Exercise Sciences, School of (Okanagan)
data provider: DSpace
degree campus: UBCO
creator: Tortoriello Romero, Juan Pablo
issued: 2024-12-20T18:04:36Z
issued: 2024
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: The potential therapeutic effects of ketosis have recently garnered attention in the scientific community and lay public. Although typically achieved by fasting or following a restrictive very-low carbohydrate diet, ketosis can now be achieved through exogenous ketone supplements, which have been shown to lower glucose and improve heart function, making them a potential therapeutic option in type 2 diabetes. However, studies conducted to date are short-term and many questions remain related to feasibility of longer-term exogenous ketone supplementation. The purpose of this research was to conduct a remote randomized double-blind, placebo-controlled pilot trial to assess the feasibility of 90 days of exogenous ketone supplementation in people living with type 2 diabetes. Twenty individuals living with type 2 diabetes were randomized to consume an exogenous ketone supplement (n=10, 59 mL of flavored concentrate containing 5 g free beta-hydroxybutyric acid + 5 g of the ketone precursor 1,3-butanediol) or a volume, taste- and pH-matched placebo (n=10) three times per day for 90 days. All trial procedures were conducted remotely. The main feasibility outcomes were recruitment rate, compliance/adherence, and participant retention/completion of the trial. Preliminary efficacy outcomes included blood glucose regulation (hemoglobin A1c, continuous glucose monitoring), cardiovascular disease risk factors (waist circumference, blood pressure, blood lipids), and general health questionnaires (physical activity, general health perception, food cravings, and dietary intake). Twenty participants were recruited primarily through specialized third-party social media advertising across ~6 months. Four participants dropped out of the exogenous ketone group due to gastrointestinal issues (n=2) or urge to vomit (n=2) and one participant dropped out of the placebo group due to drink taste. The remaining participants self-reported adherence to thrice daily drink consumption which was gene…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/89960
note: EXAMINING THE FEASIBILITY OF PROLONGED KETONE SUPPLEMENT DRINK CONSUMPTION IN ADULTS LIVING WITH TYPE 2 DIABETES by Juan Pablo Tortoriello Romero M.D. Universidad Anáhuac Mexico | Norte, 2019 A THESIS SUBMITED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE COLLEGE OF GRADUATE STUDIES (Health and Exercise Sciences) THE UNIVERSITY OF BRITISH COLUMBIA (Okanagan) December 2024 © Juan Pablo Tortoriello Romero, 2024 ii The following individuals certify that they have read, and recommend to the College of Graduate Studies for acceptance, a thesis entitled: Examining the Feasibility of Prolonged Ketone Supplement Drink Consumption in Adults Living with Type 2 Diabetes submitted by Juan Pablo Tortoriello Romero in partial fulfillment of the requirements of the degree of Master of Science. Dr. Jonathan P. Little, School of Health and Exercise Sciences_________________________________ Supervisor Dr. Sarah Purcell, School of Health and Exercise Sciences____________________________________ Supervisor Committee Member Dr. Darren Candow, University of Regina________________________________________________ Supervisor Committee Member Dr. Brodie Sakakibara, University of British Columbia (Vancouver)____________________________ University Examiner iii Abstract The potential therapeutic effects of ketosis have recently garnered attention in the scientific community and lay public. Although typically achieved by fasting or following a restrictive very-low carbohydrate diet, ketosis can now be achieved through exogenous ketone supplements, which have been shown to lower glucose and improve heart function, making them a potential therapeutic option in type 2 diabetes. However, studies conducted to date are short-term and many questions remain related to feasibility of longer-term exogenous ketone supplementation. The purpose of this research was to conduct a remote randomized double-blind, placebo-controlled pilot trial to assess the feasibility of …
has type: Thesis/Dissertation
date issued: 2025-02
is shown at: 10.14288/1.0447585
language: eng
degree discipline: Health and Exercise Sciences
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Little, Jonathan P.
type: Text
identifier URI: http://hdl.handle.net/2429/89960