Feasibility of high-intensity interval training in perimenopause to promote cognitive function and brain health
department or school: Medicine, Faculty of
department or school: Occupational Science and Occupational Therapy, Department of
department or school: Physical Therapy, Department of
data provider: DSpace
degree campus: UBCV
creator: Cirone, Victoria
issued: 2024-12-02T20:43:16Z
issued: 2024
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Sixty-one percent of Canadians with dementia are female. Neuroendocrine changes during perimenopause may contribute to females’ higher prevalence of dementia. Perimenopause is a critical window to promote female brain health. Exercise is a promising strategy targeting a key modifiable risk factor for dementia — physical inactivity — and promotes cognitive function. High-intensity interval training (HIIT) involves anaerobic exercise intervals interspersed with aerobic rest periods and improves cardiorespiratory fitness. High-intensity interval training addresses the lack-of-time barrier to exercise experienced by many perimenopausal females. High-intensity interval training’s effects on cognitive function and brain health in perimenopausal females has not been examined. Thus, I conducted a feasibility study to assess the feasibility, safety, and explore the effects of 12 weeks of HIIT on cardiorespiratory fitness, verbal episodic memory, and structural neuroimaging outcomes. Feasibility outcomes include: 1) recruitment rate (primary feasibility outcome); 2) adherence; and 3) withdrawal rate. Safety was assessed by the number of most-likely or definitely-related adverse events. Cardiorespiratory fitness was assessed by maximal oxygen consumption (VO2max). Verbal episodic memory was assessed by Rey Auditory Verbal Learning Test immediate and 30-minute delayed recall. Total, left, and right hippocampal volume were measured by T1-weighted magnetic resonance imaging. Myelin content was measured by myelin water fraction. The traffic light system for feasibility criteria categorized feasibility outcomes as: 1) go; 2) amend; or 3) stop. Point estimates for the secondary objective outcomes included mean change, standard deviation, percent change, and Cohen’s d. Sixteen perimenopausal females (mean age = 48.94 years) were recruited in 21 months. Eleven participants were included in the point estimate analysis. Recruitment rate (0.76 participants per month) and withdrawal rate …
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/89769
note: FEASIBILITY OF HIGH-INTENSITY INTERVAL TRAINING IN PERIMENOPAUSE TO PROMOTE COGNITIVE FUNCTION AND BRAIN HEALTH by Victoria Cirone B.Sc., McMaster University, 2022 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Rehabilitation Sciences) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) November 2024 © Victoria Cirone, 2024 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the thesis entitled: Feasibility of High-Intensity Interval Training in Perimenopause to Promote Cognitive Function and Brain Health submitted by Victoria Cirone in partial fulfilment of the requirements for the degree of Master of Science in Rehabilitation Sciences Examining Committee: Teresa Liu-Ambrose, Professor, Department of Physical Therapy, University of British Columbia Supervisor Cindy Barha, Assistant Professor, Faculty of Kinesiology, University of Calgary Supervisory Committee Member Nárlon Cássio Boa Sorte Silva, Assistant Professor, Department of Health, Kinesiology & Applied Physiology, Concordia University Supervisory Committee Member Todd Handy, Professor, Department of Psychology, University of British Columbia Supervisory Committee Member Linda Li, Professor, Department of Physical Therapy, University of British Columbia Additional Examiner iii Abstract Sixty-one percent of Canadians with dementia are female. Neuroendocrine changes during perimenopause may contribute to females’ higher prevalence of dementia. Perimenopause is a critical window to promote female brain health. Exercise is a promising strategy targeting a key modifiable risk factor for dementia — physical inactivity — and promotes cognitive function. High-intensity interval training (HIIT) involves anaerobic exercise intervals interspersed with aerobic rest periods and improves cardiorespiratory fitness. High-intensity interval …
has type: Thesis/Dissertation
date issued: 2025-05
is shown at: 10.14288/1.0447395
language: eng
degree discipline: Rehabilitation Sciences
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Liu-Ambrose, Teresa
type: Text
identifier URI: http://hdl.handle.net/2429/89769