The role of inflammation in oral potentially malignant lesions
department or school: Dentistry, Faculty of
data provider: DSpace
degree campus: UBCV
creator: Lin, Iris
issued: 2024-10-22T16:26:52Z
issued: 2024
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Cancer is known as the “wound that never heals,” in reference to its capacity to dysregulate the inflammatory process to facilitate tumour growth and invasion. While these mechanisms have been extensively studied across various cancer types, the role of inflammation in oral potentially malignant disorders (OPMD) remains largely understudied. The overarching objective of this work was to explore whether chronic inflammation influences the clinical and histological behaviour of OPMD. To this end, we first conducted a clinicopathological analysis of lichenoid mucositis with dysplasia (LMD), to assess whether the histological features seen in these lesions are indicative of malignant risk or a reactive byproduct of intense inflammation. We found that the dysplasia seen in these lesions are still apt to progress, and warrant clinical monitoring. The oral cavity, being accessible to routine screening, presents a unique opportunity for the early detection and prevention of cancer; this project uncovered certain clinical features that were associated with risk and which may aid in diagnosis, early detection, and clinical management. To further understand the biology of these lesions, we optimized a multiplexed staining protocol coupled with a machine-based digital pathology platform to quantify key antitumourigenic and pro-tumourigenic immune cells in dysplasia with and without lichenoid inflammation, before testing the association of these cells with malignant progression. We found that LMD presented with immune cell patterns characteristic of oral lichen planus (OLP), providing some insight into the pathogenesis of a disease group that has been subject to heavy debate. Irrespective of lichenoid features, we found activation of both anti- and pro-tumourigenic immune cell populations in low-grade dysplasia, in line with the immunoediting theory. Progressing cases showed a greater proportion of CD163+ and CD8+FOXP3+ cells, and a lesser proportion of CD8+ cells, indicating th…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/89473
note: THE ROLE OF INFLAMMATION IN ORAL POTENTIALLY MALIGNANT LESIONS by Iris Lin B.D.Sc., The University of British Columbia, 2017 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Craniofacial Science) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) October 2024 © Iris Lin, 2024 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the dissertation entitled: The role of inflammation in oral potentially malignant lesions submitted by Iris Lin in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Craniofacial Science Examining Committee: Dr. Denise Laronde, Professor, Faculty of Dentistry, University of British Columbia (UBC) Supervisor Dr. Lewei Zhang, Professor, Faculty of Dentistry, UBC Supervisory Committee Member Dr. Kristin Campbell, Associate Professor, Faculty of Medicine, UBC University Examiner Dr. Charles Shuler, Professor, Faculty of Dentistry, UBC University Examiner Additional Supervisory Committee Members: Dr. Martial Guillaud, Senior Scientist, Integrative Oncology, BC Cancer Research Centre Supervisory Committee Member Dr. Miriam Rosin, Senior Scientist, Cancer Control Research, BC Cancer Research Centre Supervisory Committee Member Dr. Leigha Rock, Associate Professor, Faculty of Dentistry, Dalhousie University Supervisory Committee Member iii Abstract Cancer is known as the “wound that never heals,” in reference to its capacity to dysregulate the inflammatory process to facilitate tumour growth and invasion. While these mechanisms have been extensively studied across various cancer types, the role of inflammation in oral potentially malignant disorders (OPMD) remains largely understudied. The overarching objective of this work was to explore whether chronic inflammation influences the clinical and histological behaviour of OPMD. To this en…
has type: Thesis/Dissertation
date issued: 2024-11
is shown at: 10.14288/1.0447067
language: eng
degree discipline: Craniofacial Science
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Laronde, Denise
type: Text
identifier URI: http://hdl.handle.net/2429/89473