Understanding the geometry of emotion
department or school: Medicine, Faculty of
data provider: DSpace
degree campus: UBCV
creator: Lindsay, Adrian John
issued: 2024-08-29T20:39:38Z
issued: 2024
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: A large body of experimental evidence across humans, primates, and rodents implicates the anterior cingulate cortex (ACC) as a component of emotional cognition. Studies of neural correlates have shown a wide variety of information being represented, including behaviour and emotional state, and previous work suggests that ACC constructs combined, complex representations of context from this variety of information, which is passed on to downstream areas concerned with emotional or autonomic state. Previous analyses in our lab have demonstrated that emotional state plays a role in this overall context, and that other representations such as behaviour are likely modulated by this emotional context. To tease apart these representations, describe their properties, and investigate how the contextualisation of representations by emotional state is functionally achieved we built and adapted a set of machine learning tools and analyses and applied it to our experimental paradigm of conditioned emotionally relevant outcomes, the ‘3-valence task’. We first built and applied HUB-DT, and unsupervised behavioural discovery tool, and generated a complete description of behaviour during our experimental task. Then, we utilised these complete sets of behavioural labels in conjunction with ACC recordings to disambiguate behaviour and emotional state in ACC, and quantify how these representations were related. Finally, we built and applied a novel neural network analysis approach, called the Neural Trajectory Point Net (NTPN) to extract the geometry of representations, their features and differences, and to gain an understanding of how their representational geometry is informed by their functional relationship. The results suggest that context representations in ACC are organized primarily by emotional state. Representations of behaviour, and likely other factors, are geometrically stable but are modulated or transformed by the influence of emotional state to form a combined context s…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/89104
note: UNDERSTANDING THE GEOMETRY OF EMOTION by Adrian John Lindsay BSc, The University of British Columbia, 2008 BCS, The University of British Columbia, 2012 MSc, The University of British Columbia, 2018 A thesis submitted in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Neuroscience) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) August 2024 © Adrian John Lindsay, 2024 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the dissertation entitled: Understanding the Geometry of Emotion submitted by Adrian John Lindsay in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Neuroscience Examining Committee: Dr. Jeremy Seamans, Professor, Department of Psychiatry, UBC Supervisor Dr. Timothy Murphy, Professor, Department of Psychiatry, UBC Supervisory Committee Member Dr. Stan Floresco, Professor, Department of Psychology, UBC Supervisory Committee Member Dr. Nicholas Swindale, Professor, Department of Ophthalmology, UBC University Examiner Dr. Steve Wolfman, Professor of Teaching, Department of Computer Science, UBC University Examiner Dr. Bruno Averbeck, Section Chief: Learning and Decision Making, National Institute of Mental Health External Examiner Additional Supervisory Committee Members: Dr. Helge Rhodin, Professor, Head of Visual AI for Extended Reality, Bielefeld University Supervisory Committee Member iii ABSTRACT A large body of experimental evidence across humans, primates, and rodents implicates the anterior cingulate cortex (ACC) as a component of emotional cognition. Studies of neural correlates have shown a wide variety of information being represented, including behaviour and emotional state, and previous work suggests that ACC constructs combined, complex representations of context from this variety of information, which is passed on to downstream areas conce…
has type: Thesis/Dissertation
date issued: 2024-11
is shown at: 10.14288/1.0445225
language: eng
degree discipline: Neuroscience
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Seamans, Jeremy
type: Text
identifier URI: http://hdl.handle.net/2429/89104