Clinical applications of 3D polymer gel dosimetry with cone-beam computed tomography readout in dosimetric and spatial accuracy verification
department or school: Science, Irving K. Barber Faculty of (Okanagan)
department or school: Computer Science, Mathematics, Physics and Statistics, Department of (Okanagan)
data provider: DSpace
degree campus: UBCO
creator: Kunkyab, Tenzin
issued: 2024-08-01T16:56:39Z
issued: 2024
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Radiation therapy is used to treat various types of cancers. The technologies in radiation delivery continue to advance rapidly. Currently, we are able to accurately target a radiation beam to a tumour volume by conforming the shape of the beam to the complex tumour shape. However, with that, there is a need for radiation dose detection tools that accurately capture the complex dose distribution in 3D space in order to verify the accuracy and precision of a treatment delivery. The purpose of this work is to implement a promising solution to this clinical challenge that utilizes a 3D NIPAM polymer gel dosimetry system with CBCT readout to verify the dosimetric and spatial accuracy of stereotactic radiosurgery (SRS) and spatially fractionated radiotherapy (SFRT) technique. Three main objectives of this work are 1) to evaluate the reproducibility of a NIPAM gel dosimetry workflow between two institutions, by implementing three identical verification plans in order to demonstrate its wide scale applicability in commissioning advanced radiotherapy techniques. In the study, two separate gel analysis pipelines were utilized based on the individual institution’s preference. 2) to commission two SRS techniques; HyperArc® (Varian Medical Systems, Palo Alto CA) to treat brain metastases and a virtual cone technique to treat trigeminal neuralgia. In the virtual cone study, an end-to-end spatial accuracy test of the treatment delivery was performed using a 3D printed anthropomorphic phantom. The dosimetric accuracy of the gel dosimetry system was benchmarked against a gold standard, film dosimeter. 3) utilizing a traditional dosimeter solely to verify the treatment delivery accuracy of SFRT is incredibly challenging and inefficient due to the heterogenous dose distribution generated in three-dimensional space. Therefore, goal of the final study is to demonstrate the application of the gel dosimetry system to commission SFRT technique. A semi-automated SFRT planning approach was …
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/88830
note: CLINICAL APPLICATIONS OF 3D POLYMER GEL DOSIMETRY WITH CONE-BEAM COMPUTED TOMOGRAPHY READOUT IN DOSIMETRIC AND SPATIAL ACCURACY VERFICATION by Tenzin Kunkyab MSc., The University of British Columbia, 2020 BSc., Maastricht University, 2017 A DISSERTATION SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE COLLEGE OF GRADUATE STUDIES (MEDICAL PHYSICS) THE UNIVERSITY OF BRITISH COLUMBIA (Okanagan) July 2024 © Tenzin Kunkyab, 2024 ii The following individuals certify that they have read, and recommend to the College of Graduate Studies for acceptance, the dissertation entitled: CLINICAL APPLICATIONS OF 3D POLYMER GEL DOSIMETRY WITH CONE-BEAM COMPUTED TOMOGRAPHY READOUT IN DOSIMETRIC AND SPATIAL ACCURACY VERFICATION submitted by Tenzin Kunkyab in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Medical Physics Examining Committee: Dr. Andrew Jirasek, I. K. Barber School of Arts & Sciences Supervisor Dr. Derek Hyde, I.K. Barber School of Arts & Sciences Supervisory Committee Member Dr. Jeff Andrews, I. K. Barber School of Arts & Sciences Supervisory Committee Member Dr. Nathan Becker, I. K. Barber School of Arts & Sciences Supervisory Committee Member Dr. Zheng Liu, School of Engineering University Examiner Dr. Chris Thomas, Department of Radiation Oncology, Dalhousie University External Examiner iii Abstract Radiation therapy is used to treat various types of cancers. The technologies in radiation delivery continue to advance rapidly. Currently, we are able to accurately target a radiation beam to a tumour volume by conforming the shape of the beam to the complex tumour shape. However, with that, there is a need for radiation dose detection tools that accurately capture the complex dose distribution in 3D space in order to verify the accuracy and precision of a treatment delivery. The purpose of this work is to implement a promising solution to this clinical challenge that utilizes a 3D NIPAM …
has type: Thesis/Dissertation
date issued: 2024-09
is shown at: 10.14288/1.0444959
language: eng
degree discipline: Medical Physics
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Jirasek, Andrew
type: Text
identifier URI: http://hdl.handle.net/2429/88830