Examining the association between in-vitro fertilization and severe maternal morbidity in the United States and Canada
department or school: Medicine, Faculty of
department or school: Obstetrics and Gynaecology, Department of
data provider: DSpace
degree campus: UBCV
creator: Victory, Jenna
issued: 2024-08-01T22:10:14Z
issued: 2024
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Infertility, the inability to conceive after twelve or more months of regular unprotected sexual intercourse, affects approximately 1 in 6 people globally. Fertility rates are declining worldwide, and use of assisted reproductive technologies like in-vitro fertilization (IVF) to conceive is increasing. Racial/ethnic disparities in SMM among women who conceived via IVF are understudied. In addition, the association between IVF conception and HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome during pregnancy has not been quantified on the population level, distinctively in singleton and twin pregnancy. I conducted a population-based retrospective cohort study of all singleton births between 20-44 weeks in the United States between 2016-2021 using live birth and fetal death certificate data. The objective of this study was to quantify the association between IVF and SMM and to ascertain if the association was modified by race/ethnicity. Women who conceived by IVF had a two-fold higher rate of the SMM composite outcome. This higher risk was observed across all racial/ethnic groups. Racial/ethnic disparities were present in women who conceived spontaneously. Women who conceived by IVF generally had similar racial/ethnic disparities. However, these disparities in uterine rupture/intrapartum hysterectomy were larger for Hispanic women who conceived by IVF than spontaneously, and for NHB women who conceived by IVF than spontaneously. Asian women who used IVF also had greater odds of admission to the ICU than those who conceived spontaneously. I conducted a second population-based retrospective cohort study of all singleton and twin live births and stillbirths between 20-44 weeks in British Columbia, Canada, between 2008/09-2021/22. This study attempted to address whether spontaneous versus IVF conception was associated with HELLP syndrome among singleton/twin pregnancies. Women who conceived twins spontaneously had higher risk of HELLP syndrome than women w…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/88846
note: EXAMINING THE ASSOCIATION BETWEEN IN-VITRO FERTILIZATION AND SEVERE MATERNAL MORBIDITY IN THE UNITED STATES AND CANADA by Jenna Victory B.Sc., The University of Edinburgh, 2022 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in The Faculty of Graduate and Postdoctoral Studies (Women+ and Children’s Health Sciences) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) July 2024 © Jenna Victory, 2024 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the thesis entitled: Examining the association between in-vitro fertilization and severe maternal morbidity in the United States and Canada submitted by Jenna Victory in partial fulfilment of the requirements for the degree of Master of Science in Women+ and Children’s Health Sciences Examining Committee: Sarka Lisonkova, Associate Professor, Department of Obstetrics and Gynaecology, UBC Supervisor KS Joseph, Professor, Department of Obstetrics and Gynaecology, UBC Supervisory Committee Member Paul Yong, Associate Professor, Department of Obstetrics and Gynaecology, UBC Additional Examiner Additional Supervisory Committee Members: Hamideh Bayrampour, Assistant Professor, Department of Family Practice, UBC Supervisory Committee Member iii ABSTRACT Infertility, the inability to conceive after twelve or more months of regular unprotected sexual intercourse, affects approximately 1 in 6 people globally. Fertility rates are declining worldwide, and use of assisted reproductive technologies like in-vitro fertilization (IVF) to conceive is increasing. Racial/ethnic disparities in SMM among women who conceived via IVF are understudied. In addition, the association between IVF conception and HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome during pregnancy has not been quantified on the population level, distinctively in singleton and twin pregnancy. I conducted a population-based r…
has type: Thesis/Dissertation
date issued: 2024-11
is shown at: 10.14288/1.0444951
language: eng
degree discipline: Women+ and Children’s Health Sciences
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Lisonkova, Sarka
type: Text
identifier URI: http://hdl.handle.net/2429/88846