Investigating cerebellar involvement in the adaptability of standing balance control using a robotic platform and electroencephalography
department or school: Applied Science, Faculty of
department or school: Mechanical Engineering, Department of
data provider: DSpace
degree campus: UBCV
creator: Qiao, Zhuhan (Calvin)
issued: 2024-07-04T18:24:56Z
issued: 2024
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Standing balance deficits are common in aging populations and individuals with neurological disorders, including patients with traumatic brain injuries. Despite the prevalence, the neural mechanisms underlying such deficits remain unclear. Existing standing balance tests mainly focus on global postural stability metrics, often neglecting the roles of individual sensory organs and neural components. Therefore, new methods are required to better probe the standing balance circuit. The cerebellum emerges as a key neural center for managing standing balance control and its adaptability. While human-in-the-loop robotic balance platforms have been used to test balance adaptability, they are limited to the anteroposterior direction and lack direct cerebellar measurements. To address these limitations and investigate the underlying mechanisms of standing balance control deficits, this thesis has the following objectives: (1) conduct a literature review to summarize standing balance deficits, current test paradigms and their limitations, with a focus on patients with concussions, (2) achieve multidirectional control on a human-in-the-loop balance robot by adding mediolateral (ML) capabilities, (3) develop an accurate kinematics model for ML balance simulation, and (4) develop an experimental protocol that combines electroencephalography (EEG) with the robot to measure cerebellar activity during adaptation. The literature review confirmed relatively consistent post-concussion global balance stability changes and highlighted the need to develop more specific methodologies to probe the balance control circuit. After upgrading the balance robot to include ML control, its motion tracking performance achieved delays under 15 ms and submillimeter errors. A multi-segmental kinematics ML balance model was developed, validated through experiments, and improved through data-driven refinements. The refined model reduced root mean squared errors of the estimated trunk/pelvis position by …
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/88568
note: INVESTIGATING CEREBELLAR INVOLVEMENT IN THE ADAPTABILITY OF STANDING BALANCE CONTROL USING A ROBOTIC PLATFORM AND ELECTROENCEPHALOGRAPHY by Zhuhan (Calvin) Qiao M.S., Carnegie Mellon University, 2019 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Mechanical Engineering) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) June 2024 © Zhuhan (Calvin) Qiao, 2024 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the dissertation entitled: Investigating Cerebellar Involvement in the Adaptability of Standing Balance Control Using a Robotic Platform and Electroencephalography submitted by Zhuhan (Calvin) Qiao in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Mechanical Engineering Examining Committee: Lyndia Wu, Assistant Professor, Department of Mechanical Engineering, UBC Supervisor Jean-Sébastien Blouin, Professor, School of Kinesiology, UBC Co-supervisor Bryan Gick, Professor, Department of Linguistics, UBC University Examiner Peter Cripton, Professor, School of Biomedical Engineering, UBC University Examiner Jean Blouin, Professor, Laboratoire de Neurosciences Cognitives, Aix-Marseille University External Examiner Additional Supervisory Committee Members: Agnes d’Entremont, Associate Professor of Teaching, Department of Mechanical Engineering, UBC Supervisory Committee Member Julia Schmidt, Assistant Professor, Department of Occupational Science and Occupational Therapy, UBC Supervisory Committee Member iii Abstract Standing balance deficits are common in aging populations and individuals with neurological disorders, including patients with traumatic brain injuries. Despite the prevalence, the neural mechanisms underlying such deficits remain unclear. Existing standing balance tests mainly focus on global postural stability metrics, often neglect…
has type: Thesis/Dissertation
date issued: 2024-11
is shown at: 10.14288/1.0444084
language: eng
degree discipline: Mechanical Engineering
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Wu, Lyndia
contributor: Blouin, Jean-Sébastien
type: Text
identifier URI: http://hdl.handle.net/2429/88568