Surface photosterilization of implantable biomaterials : applications in urology and dentistry
department or school: Medicine, Faculty of
department or school: Medicine, Department of
data provider: DSpace
degree campus: UBCV
creator: Ayatallah Ghaffari, Sahand
issued: 2024-05-03T18:51:39Z
issued: 2024
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Despite numerous advantages and versatile applications, medical implants suffer from bacterial colonization and biofilm formation that can lead to many complications. Despite a great degree of effort being put into research and development of antimicrobial technologies, there remains an unmet need for a technology that can be incorporated and applied to a variety of polymeric biomaterials in various fields of medicine and in different settings to decontaminate implant surfaces and reduce biofilm formation and further infection. This thesis is an effort to offer a practical alternative antimicrobial technology using surface photosterilization of both silicone-based urinary catheters and methacrylate-based dental resin fillers that are embedded with a ruthenium (Ru) photosensitizer (PS) and are activated using a LED light source. Throughout this work, the synthesis and characterization of the PS and incorporation methods into both polymers are discussed, and a set of experiments are performed to identify the chemical, physical, and mechanical properties of the final biomaterials. Both Ru-embedded polymers underwent rigorous testing to evaluate their antimicrobial efficacy as surface decontaminating agents for both short (15 min) and prolonged (24 h) periods of LED exposure time which resulted in significant reduction in surface-adhered bacteria and biofilm maturation. These findings can pave the way for successful implementation of photosterilization as a technology with great potential to significantly reduce the extent of both catheter-associated urinary tract infection (CAUTI) and caries-inducing oral infections.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/88205
note: Surface Photosterilization of Implantable Biomaterials: Applications in Urology and Dentistry by Sahand Ayatallah Ghaffari B.Sc., Bogazici University, 2016 M.Sc., Bogazici University, 2018 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Experimental Medicine) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) April 2024 © Sahand Ayatallah Ghaffari, 2024 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the dissertation entitled: Surface Photosterilization of Implantable Biomaterials: Applications in Urology and Dentistry submitted by Sahand Ayatallah Ghaffari in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Experimental Medicine Examining Committee: Dirk Lange, Associate Professor, Department of Urologic Sciences, UBC Supervisor Neil R. Branda, Professor, Department of Chemistry, Simon Fraser University Co-supervisor Ben H. Chew, Associate Professor, Department of Urologic Sciences, UBC Supervisory Committee Member Jayachandran Kizhakkedathu, Professor, Department of Pathology and Laboratory Medicine, UBC University Examiner David J. Granville, Professor, Department of Pathology and Laboratory Medicine, UBC University Examiner Additional Supervisory Committee Members: Adriana P. Manso, Associate Professor, Faculty of Dentistry, UBC Supervisory Committee Member iii Abstract Despite numerous advantages and versatile applications, medical implants suffer from bacterial colonization and biofilm formation that can lead to many complications. Despite a great degree of effort being put into research and development of antimicrobial technologies, there remains an unmet need for a technology that can be incorporated and applied to a variety of polymeric biomaterials in various fields of medicine and in different settings to decontaminate implant surfac…
has type: Thesis/Dissertation
date issued: 2024-11
is shown at: 10.14288/1.0442274
language: eng
degree discipline: Experimental Medicine
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Lange, Dirk (Microbiologist)
contributor: Branda, Neil R.
type: Text
identifier URI: http://hdl.handle.net/2429/88205