Optimization of a lower body negative pressure chamber to control the left ventricular pressure of rodents
department or school: Applied Science, Faculty of
department or school: Engineering, School of (Okanagan)
data provider: DSpace
degree campus: UBCO
creator: Hajati, Nasim
issued: 2024-04-22T15:09:46Z
issued: 2024
related degree: Master of Applied Science - MASc
degree grantor: University of British Columbia
description: Assessing the performance of the cardiovascular system is a crucial part of testing new medications and biomedical devices. To ensure the safety of these new products, it is necessary that their impact on performance factors, such as the strength or elasticity of the heart muscles be evaluated. These tests are typically performed on animals; specifically, rodents have been playing a significant role in such biomedical experimentations. Traditional methods of studying the cardiovascular system involve invasive surgeries to reach the heart and its vessels, to manually manipulate the blood return flow to the left ventricle and monitor the change in the patterns of ventricular or arterial pressure and volume through plotting pressure-volume graphs. These surgical methods often lead to blood loss or damage to vessels and organs of the rodents, which affects the test results, making them less accurate. They are also subject to human error which leads to low repeatability. Considering the issues of the traditional approaches, the literature suggests using a manually-operated Lower Body Negative Pressure (LBNP) chamber as a non-invasive alternative. This approach places sealed chambers around the lower body of the rodents and creates suction inside the chamber to control the blood flow to the heart by drawing the blood toward the lower body as an effect of the negative pressure. To remove direct human intervention, an automated servo-controlled system was built by previous UBC students, which controlled the blood pressure level, to be later plotted against the measured volume. This study aims to fix the shortcomings of that device, including low interface speed and lack of safety features for the electronics. In addition, this study performs system identification on the automated chamber and rodents’ left ventricular pressure models and designs a robust controller for the system based on the derived models.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/87913
note: OPTIMIZATION OF A LOWER BODY NEGATIVE PRESSURE CHAMBER TO CONTROL THE LEFT VENTRICULAR PRESSURE OF RODENTS by Nasim Hajati B.Sc., Sharif University of Technology, 2021 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF APPLIED SCIENCE in THE COLLEGE OF GRADUATE STUDIES (Electrical Engineering) THE UNIVERSITY OF BRITISH COLUMBIA (Okanagan) April 2024 © Nasim Hajati, 2024 ii The following individuals certify that they have read, and recommend to the College of Graduate Studies for acceptance, the thesis entitled: Optimization of a Lower Body Negative Pressure Chamber to Control the Left Ventricular Pressure of Rodents submitted by Nasim Hajati in partial fulfilment of the requirements of the degree of Master of Applied Science . Rudolf Seethaler, School of Engineering Supervisor Klaske Van Heusden, School of Engineering Supervisory Committee Member Ahmad Al-Dabbagh, School of Engineering Supervisory Committee Member Sumi Siddiqua, School of Engineering University Examiner iii Abstract Assessing the performance of the cardiovascular system is a crucial part of testing new medications and biomedical devices. To ensure the safety of these new products, it is necessary that their impact on performance factors, such as the strength or elasticity of the heart muscles be evaluated. These tests are typically performed on animals; specifically, rodents have been playing a significant role in such biomedical experimentations. Traditional methods of studying the cardiovascular system involve invasive surgeries to reach the heart and its vessels, to manually manipulate the blood return flow to the left ventricle and monitor the change in the patterns of ventricular or arterial pressure and volume through plotting pressure-volume graphs. These surgical methods often lead to blood loss or damage to vessels and organs of the rodents, which affects the test results, making them less accurate. They are also subject to human error which leads to l…
has type: Thesis/Dissertation
date issued: 2024-05
is shown at: 10.14288/1.0441469
language: eng
degree discipline: Electrical Engineering
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Seethaler, Rudolf
type: Text
type: Still Image
identifier URI: http://hdl.handle.net/2429/87913