A patient-specific treatment technology suite for interstitial gynaecological brachytherapy
department or school: Science, Irving K. Barber Faculty of (Okanagan)
department or school: Computer Science, Mathematics, Physics and Statistics, Department of (Okanagan)
data provider: DSpace
degree campus: UBCO
creator: Kudla-Hooper, Michael William
issued: 2023-08-10T23:14:01Z
issued: 2023
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Purpose: Delivering conformal treatment plans for high dose rate (HDR) gynaecological (GYN) brachytherapy (BT) using commercially available applicators can be challenging in many clinical cases. The intent of this work is to describe a treatment technology suite developed to enable treatment customization for patients with difficult-to-treat gynaecological malignancies. Methods: A workflow has been created for the creation of patient-specific cylindrical templates (PSCTs), which facilitate preplanned needle trajectories for interstitial (IS) Vaginal HDR-BT. This includes software for design automation, manufacturing processes, and sterilization. The workflow was evaluated for pre-clinical feasibility, including dosimetry, sterilization, and manufacturing quality. The Tandem and Cylinder (T&C) template has been developed for the treatment of cervical malignancies, and has a standard design which can be customized for difficult treatment cases. Both devices were evaluated in treatment cohorts, assessing preplan reproducibility, treatment dosimetry, outcomes, and practicality. A novel, easy-to-use, and fast software algorithm to generate candidate needle trajectory sets for GYN HDR-BT PSCTs is presented. Auto-planned trajectory set-based preplans were compared to original patient preplans for a retrospective patient cohort. Results: Needle trajectories can be exported directly from treatment planning software and converted into a 3D printable PSCT. PSCTs are shown to be manufactured to a clinical quality, and sterilizable. Prospective treatment plans are shown to be equivalent or improved as compared to highly specialized modern techniques. Both treatment cohorts for both PSCTs and T&C patients showed excellent treatment dosimetry, needle position reproducibility, and outcome. Auto-planner-based preplans were of high clinical quality, were equivalent in dosimetry to manually created preplans, and treatment plan libraries were able to be created very quickly. Conclusion…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/85443
note: A PATIENT-SPECIFIC TREATMENT TECHNOLOGY SUITE FOR INTERSTITIALGYNAECOLOGICAL BRACHYTHERAPYbyMichael William Kudla-HooperB.Sc., Physics, Walla Walla University, 2014B.Sc., Mechanical Engineering, Walla Walla University, 2014M.Sc., Medical Physics, The University of British Columbia, 2019A DISSERTATION SUBMITTED IN PARTIAL FULFILLMENT OFTHE REQUIREMENTS FOR THE DEGREE OFDOCTOR OF PHILOSOPHYinTHE COLLEGE OF GRADUATE STUDIES(Medical Physics)THE UNIVERSITY OF BRITISH COLUMBIA(Okanagan)©July 2023The following individuals certify that they have read, and recommend to the College of GraduateStudies for acceptance, a thesis/dissertation entitled:A PATIENT-SPECIFIC TREATMENT TECHNOLOGY SUITE FOR INTERSTITIALGYNAECOLOGICAL BRACHYTHERAPYsubmitted by Michael William Kudla-Hooper in partial fulfillment of the requirements of the degreeof Doctor of Philosophy.Andrew Jirasek, Ph.D., IKBSAS - PhysicsSupervisorDeidre Batchelar, Ph.D., IKBSAS - Physics & BC Cancer KelownaCo-SupervisorTony Teke, Ph.D., IKBSAS - Physics & BC Cancer KelownaSupervisory Committee MemberAlex Hill, Ph.D., IKBSAS - PhysicsSupervisory Committee MemberKlaske van Heusden, Ph.D., School of EngineeringUniversity ExaminerGeetha Menon, Ph.D., University of AlbertaExternal ExamineriiAbstractPurpose: Delivering conformal treatment plans for high dose rate (HDR) gynaecological (GYN)brachytherapy (BT) using commercially available applicators can be challenging in many clinical cases.The intent of this work is to describe a treatment technology suite developed to enable treatmentcustomization for patients with difficult-to-treat gynaecological malignancies.Methods: A workflow has been created for the creation of the patient-specific cylindrical template(PSCT), a novel treatment device, which facilitates preplanned needle trajectories for interstitial (IS)Vaginal HDR-BT. This novel workflow includes software for design automation, manufacturing pro-cesses, and sterilization. The workflow was evaluated for pre-clinical fea…
has type: Thesis/Dissertation
date issued: 2023-09
is shown at: 10.14288/1.0435167
language: eng
degree discipline: Medical Physics
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Jirasek, Andrew
contributor: Batchelar, Deidre
type: Text
identifier URI: http://hdl.handle.net/2429/85443