Physiological computations underlying our internal representation of vestibular self-motion
department or school: Education, Faculty of
department or school: Kinesiology, School of
data provider: DSpace
degree campus: UBCV
creator: Chen, Anthony
issued: 2023-08-09T17:33:39Z
issued: 2023
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Humans, as with other organisms, rely on sensing for survival. The principles implemented by the brain to interpret this sensory information; however, remain open for investigation. The vestibular sense provides information about self-motion and orientation, which in part allows us to properly perceive self-motion in space and to navigate the surrounding environment. The purpose of this thesis was to advance the current knowledge of how the brain processes sensory cues of motion. Because the mechanisms that govern the central integration of vestibular information are difficult to reveal through everyday experiences, we used experimentally controlled sensory stimuli to probe vestibular-related neurophysiological and psychophysical behaviours. Studies presented in this thesis emerge from a first principles approach looking at integration of signals from primary vestibular afferents using a novel sampling-based dynamical inference model. Experiment 1 characterized perceptual self-motion during and following constant vestibular stimulation and contextualized how percepts arise from the integration of differently adapting primary vestibular afferents based on the brain’s expectation about one’s self-motion. Experiment 2 examined why perception changes when different vestibular end-organs encodes the same gravity-neutral whole-body motion. We showed that vestibular otoliths provide the brain additional information of self-rotation, a role primarily attributed to the vestibular semicircular canals. Experiments 3 and 4 together evaluated electrical vestibular stimulation for probing the vestibular system in humans. Here, we used current physiological data of primary vestibular afferent responses to both mechanical and electrical stimuli to predict and evaluate their equivalence in central processing in humans. Subsequently, a real-time solution for human-in-the-loop vestibular sense modulation using electrical vestibular stimulation during active head movements was develope…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/85423
note: PHYSIOLOGICAL COMPUTATIONS UNDERLYING OUR INTERNAL REPRESENTATION OF VESTIBULAR SELF-MOTION by Anthony Chen B.Kin., The University of British Columbia, 2016 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Kinesiology) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) August 2023 © Anthony Chen, 2023 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the dissertation entitled: Physiological Computations Underlying Our Internal Representation of Vestibular Self-motion submitted by Anthony Chen in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Kinesiology Examining Committee: Dr. Jean-Sébastien Blouin Professor, Kinesiology, University of British Columbia Supervisor Dr. Robert Boushel Professor, Kinesiology, University of British Columbia Co-supervisor Dr. Christopher J. Dakin Associate Professor, Kinesiology and Health Science, Utah State University Supervisory Committee Member Dr. Miriam Spering Professor, Ophthalmology & Visual Sciences, University of British Columbia University Examiner Dr. James Enns Professor, Psychology, University of British Columbia University Examiner iii Abstract Humans, as with other organisms, rely on sensing for survival. The principles implemented by the brain to interpret this sensory information; however, remain open for investigation. The vestibular sense provides information about self-motion and orientation, which in part allows us to properly perceive self-motion in space and to navigate the surrounding environment. The purpose of this thesis was to advance the current knowledge of how the brain processes sensory cues of motion. Because the mechanisms that govern the central integration of vestibular information are difficult to reveal through everyday experiences, we used experimentally controlled sensory sti…
has type: Thesis/Dissertation
date issued: 2023-11
is shown at: 10.14288/1.0435115
language: eng
degree discipline: Kinesiology
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Blouin, Jean-Sébastien
contributor: Boushel, Robert
type: Text
identifier URI: http://hdl.handle.net/2429/85423