Biased attentional processing associated with concurrent disorders : an event-related potential study
department or school: Medicine, Faculty of
data provider: DSpace
degree campus: UBCV
creator: Epp, Tanisse Chanel Maureen
issued: 2023-04-21T17:08:00Z
issued: 2023
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Background: Several studies have shown that substance use disorders are characterized by an enhanced attention processing of substance and substance-related cues, with lower attentional processing of non-substance-related affective cues. Additionally, previous research has shown that attentional processing, within addiction, is malleable and can reverse from enhanced processing of substance cues to pleasant cues following prolonged abstinence. This study examines the neural processing of stimulant, pleasant, and stimulant relative to pleasant cues in individuals with a concurrent diagnosis of mental health and substance use disorders (i.e., concurrent disorders) compared to controls using event-related potentials (ERPs). Methods: Within in-patient individuals with concurrent disorders (n = 33) and a control group (n = 32), we studied the P300 amplitude elicited by stimulant (stimulant – neutral), pleasant (pleasant – neutral), stimulant relative to pleasant (stimulant – pleasant) cues. Additionally, individuals completed surveys and tasks to examine the implications of diagnoses, self-reported craving, cognitive function, and affect. Results: The results indicate that in-patient participants with concurrent disorder display a larger P300 difference wave for stimulant and pleasant cues, which remained significant after controlling for age, ethnicity, and working memory, compared to controls. Conclusions: These findings suggest that larger P300 amplitudes for stimulant and pleasant cues may be explaining emotional dysregulation within concurrent disorders. Together these findings suggest that non-invasive electrophysiological measures, such as EEG, may be used within future research to investigate the differences in concurrent disorder, mental health, and substance use disorders alone, necessary for identifying shared processes among these disorders.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/84401
note: BIASED ATTENTIONAL PROCESSING ASSOCIATED WITH CONCURRENT DISORDERS: AN EVENT-RELATED POTENTIAL STUDY by TANISSE CHANEL MAUREEN EPP B.Sc., Carleton University, 2021 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Neuroscience) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) April 2023 © Tanisse Chanel Maureen Epp, 2023 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the thesis entitled: Biased attentional processing associated with concurrent disorders: an event-related potential study submitted by Tanisse Chanel Maureen Epp in partial fulfilment of the requirements for the degree of Master of Science in Neuroscience Examining Committee: Dr. Christian Schütz, Psychiatry, UBC Supervisor Dr. Catharine Winstanley, Psychology, UBC Supervisory Committee Member Dr. Rebecca Todd, Psychology, UBC Supervisory Committee Member Dr. Stanley Floresco, Psychology, UBC Additional Examiner Additional Supervisory Committee Members: Dr. Olav Krigolson, Medical Science, UVic Supervisory Committee Member iii Abstract Background: Several studies have shown that substance use disorders are characterized by an enhanced attention processing of substance and substance-related cues, with lower attentional processing of non-substance-related affective cues. Additionally, previous research has shown that attentional processing, within addiction, is malleable and can reverse from enhanced processing of substance cues to pleasant cues following prolonged abstinence. This study examines the neural processing of stimulant, pleasant, and stimulant relative to pleasant cues in individuals with a concurrent diagnosis of mental health and substance use disorders (i.e., concurrent disorders) compared to controls using event-related potentials (ERPs). Methods: Within in-patient individuals with concurrent disorder…
has type: Thesis/Dissertation
date issued: 2023-05
is shown at: 10.14288/1.0431375
language: eng
degree discipline: Neuroscience
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Schutz, Christian G.
type: Text
identifier URI: http://hdl.handle.net/2429/84401