Neuromodulatory effects of theta burst stimulation, a molecular and functional assessment
department or school: Medicine, Faculty of
data provider: DSpace
degree campus: UBCV
creator: Aceves Serrano, Lucero Guadalupe
issued: 2023-04-20T21:49:17Z
issued: 2023
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a therapeutic tool to alleviate symptoms of neurological and psychiatric disorders. Although the therapeutic potential of rTMS has been widely explored, the neurobiological basis of its effects is still not fully understood. This thesis used in vivo imaging techniques such as positron emission tomography (PET) and magnetic resonance imaging (MRI) in parallel with post-mortem evaluations to investigate the effects of a clinical course of theta burst stimulation (TBS) – a patterned form of rTMS – at the molecular and functional level in non-human primates (NHP). These techniques were employed to investigate rTMS-induced modulation of dopaminergic and glutamatergic neurotransmission, its effects on brain activity and connectivity, and glial reactivity modulation. Specifically, we evaluated the effects of rTMS in the healthy brain of NHP. Neuroimaging evaluations and cortical excitability assessments were performed before and one day after a clinical course of intermittent (iTBS), continuous (cTBS), or sham stimulation over the left motor cortex. Dopaminergic assessment using PET was also acquired immediately after the first stimulation session. Neurotransmission assessment revealed a decrease in dopamine release in the left and right putamen immediately after cTBS delivery, while no changes in neurotransmission were found in the striatum after multiple cTBS, iTBS, or sham sessions. Functional MRI revealed modulatory effects of cTBS and iTBS, but not sham delivery, between the regions of the cortico-striatal-thalamo-cortical motor loop. We found increased connectivity between the stimulated and the contralateral motor cortex. Furthermore, we found that baseline connectivity measurements were correlated to changes in dopamine release after a single stimulation session. Assessment of metabolic connectivity with PET revealed a brain-wide effect post-iTBS with no effects observed after cTBS and sham de…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/84388
note: Neuromodulatory effects of Theta Burst Stimulation, a molecular and functional assessment by Lucero Guadalupe Aceves Serrano B.Sc., Tecnologico de Monterrey, 2016 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Neuroscience) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) April 2023 © Lucero Guadalupe Aceves Serrano, 2023 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the dissertation entitled: Neuromodulatory effects of Theta Burst Stimulation, a molecular and functional assessment submitted by Lucero Guadalupe Aceves Serrano in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Neuroscience Examining Committee: Dr. Doris Doudet, Professor, Department of Neurology, UBC Supervisor Dr. Lara Boyd, Professor, Department of Physical Therapy, UBC Supervisory Committee Member Dr. Martin McKeown, Professor, Department of Neurology, UBC Supervisory Committee Member Dr. Jon Stoessl, Professor, Department of Neurology, UBC University Examiner Dr. John Kramer, Professor, Department of Anesthesiology, Pharmacology and Therapeutics, UBC University Examiner Additional Supervisory Committee Members: Dr. Vesna Sossi, Professor, Department of Physics and Astronomy, UBC Supervisory Committee Member Dr. Alex Mackay, Pofessor, Department of Physics and Astronomy, UBC Supervisory Committee Member iii Abstract Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a therapeutic tool to alleviate symptoms of neurological and psychiatric disorders. Although the therapeutic potential of rTMS has been widely explored, the neurobiological basis of its effects is still not fully understood. This thesis used in vivo imaging techniques such as positron emission tomography (PET) and magnetic resonance imaging (MRI) in parallel with post-mortem evaluations…
has type: Thesis/Dissertation
date issued: 2023-05
is shown at: 10.14288/1.0431326
language: eng
degree discipline: Neuroscience
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Doudet, Doris
type: Text
identifier URI: http://hdl.handle.net/2429/84388