Functional 3D retinal imaging using OCT technology and a novel, system-agnostic registration algorithm
department or school: Applied Science, Faculty of
department or school: Biomedical Engineering, School of
data provider: DSpace
degree campus: UBCV
creator: Siadati fini, Seyedeh Mahsa
issued: 2023-04-17T21:53:07Z
issued: 2023
related degree: Master of Applied Science - MASc
degree grantor: University of British Columbia
description: Optical coherence tomography (OCT) is a non-invasive optical imaging technique to capture in-vivo, three-dimensional (3D) image data with micrometer resolution. OCT has become a valuable tool for ophthalmologists in detecting and monitoring eye diseases like age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR) by providing valuable information for diagnosis and determining the best course of treatment. OCT angiography (OCTA) is a functional extension of OCT which allows for non-invasive visualization of blood flow in the retina and choroid. OCTA provides detailed information about microvasculature, which is not possible with traditional angiography techniques. However, OCT and OCTA images are susceptible to degradation from motion artifacts induced by the involuntary human subjects’ head and eye movement. Multi-volume acquisition and averaging is a software-based approach to correct the motion artifacts by registering several motion-corrupted images to a single reference image or multiple reference images in a post-processing step. Nonetheless, most software-based algorithms have been more specifically designed for a specific system with a limited field-of-view (FOV) range. In this study, we implemented a robust 3D algorithm for the precise registration of multiple volumes to the coordinates of one volume chosen as the reference volume. Tests were carried out on various datasets obtained from different types of custom-built and commercially available systems to determine the reliability of the proposed algorithm. A two-dimensional (2D) version of this method is then applied to investigate retinal perfusion heterogeneity, which may enhance our understanding of retinal diseases such as glaucoma.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/84221
note: Functional 3D retinal imaging using OCT technology and a novel, system-agnostic registration algorithm by Seyedeh Mahsa Siadati fini BASc., Sharif University of Technology, 2020 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF APPLIED SCIENCE in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Biomedical Engineering) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) April 2023 © Seyedeh Mahsa Siadati fini, 2023 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the thesis entitled: Functional 3D retinal imaging using OCT technology and a novel, system-agnostic registration algorithm submitted by Seyedeh Mahsa Siadati fini in partial fulfilment of the requirements for the degree of Master of Applied Science in Biomedical Engineering Examining Committee: Myeong Jin Ju, Assistant professor, Biomedical Engineering, UBC Supervisor Shou Tang, Professor, Electrical and Computer Engineering, UBC Supervisory Committee Member Jane Z. Wang, Professor, Electrical and Computer Engineering, UBC Supervisory Committee Member iii Abstract Optical coherence tomography (OCT) is a non-invasive optical imaging technique to capture in-vivo, three-dimensional (3D) image data with micrometer resolution. OCT has become a valuable tool for ophthalmologists in detecting and monitoring eye diseases like age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR) by providing valuable information for diagnosis and determining the best course of treatment. OCT angiography (OCTA) is a functional extension of OCT which allows for non-invasive visualization of blood flow in the retina and choroid. OCTA provides detailed information about microvasculature, which is not possible with traditional angiography techniques. However, OCT and OCTA images are susceptible to degradation from motion artifacts induced by the involuntary human subjects’ head and eye …
has type: Thesis/Dissertation
date issued: 2023-05
is shown at: 10.14288/1.0431067
language: eng
degree discipline: Biomedical Engineering
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nd/4.0/
scholar level: Graduate
contributor: Ju, Myeong Jin
type: Text
identifier URI: http://hdl.handle.net/2429/84221