The impact of sedentary behaviour and physical activity on cerebrovascular hemodynamics, cerebrovascular reactivity, and neurovascular coupling in children
department or school: Health and Social Development, Faculty of (Okanagan)
department or school: Health and Exercise Sciences, School of (Okanagan)
data provider: DSpace
degree campus: UBCO
creator: Tallon, Christine Marie
issued: 2022-09-28T15:39:28Z
issued: 2022
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Despite extensive literature on cerebral blood flow (CBF) regulation and cerebrovascular function in adults, there is very limited knowledge for the healthy child. Equally, as children’s daily sedentary behaviour increases, relationships between sedentary behaviour, physical activity, and cerebral hemodynamics are also poorly understood. This thesis aimed to determine the impact of sedentary behaviour on cerebrovascular function in healthy children. To achieve this objective four studies were conducted. An initial study (Chapter 3) explored relationships between habitual sedentary behaviour, physical activity, maturation, and CBF at rest in 78 children and adolescents (6 – 17 years), observing a lower internal carotid artery (ICA) shear rate in participants who engaged in >452 min of total sedentary behaviour per day. The second and third studies focused on the measurement of cerebrovascular function in children compared to adults and investigated cerebrovascular reactivity [CVR] to inspired carbon dioxide (F₁CO₂; 6%), indexed by temporal blood velocity changes (v) within the middle cerebral artery (MCA; Chapter 4) and blood flow in the ICA (QICA; Chapter 5), per unit of change in the end-tidal partial pressure of CO₂. Findings of Chapter 4 indicate similar CVR MCAv in children (n=21) and adults (n=20), but a significantly slower onset response to CO₂ in children compared to adults. Similarly, findings of Chapter 5 indicate a similar CVR ICA between children (n=14) and adults (n=17) but a slower onset response in the child. Applying knowledge of the relationship identified in Chapter 3, and the methodology used in Chapters 4 and 5, the fourth study (Chapter 6) investigated whether an acute bout of prolonged sitting (3 h) would alter cerebrovascular function and whether interrupting prolonged sitting with exercise breaks (10 min each hour) affords defence against any sitting-induced cerebrovascular disruption in children (n=31). Findings of Chapter 6 indicate an acut…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/82776
note: THE IMPACT OF SEDENTARY BEHAVIOUR AND PHYSICAL ACTIVITY ON CEREBROVASCULAR HEMODYNAMICS, CEREBROVASCULAR REACTIVITY, AND NEUROVASCULAR COUPLING IN CHILDREN by Christine Marie Tallon B.H.K., The University of British Columbia, 2015 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE COLLEGE OF GRADUATE STUDIES (Kinesiology) THE UNIVERSITY OF BRITISH COLUMBIA (Okanagan) September 2022 © Christine Marie Tallon, 2022 ii The following individuals certify that they have read, and recommend to the College of Graduate Studies for acceptance, a thesis/dissertation entitled: The impact of sedentary behaviour and physical activity on cerebrovascular hemodynamics, cerebrovascular reactivity, and neurovascular coupling in children submitted by Christine Marie Tallon in partial fulfillment of the requirements of the degree of Doctor of Philosophy. Dr. Ali McManus, School of Health and Exercise Sciences Supervisor Dr. Phil Ainslie, School of Health and Exercise Sciences Supervisory Committee Member Dr. Alan Barker, University of Exeter Supervisory Committee Member Dr. Christine Voss, Faculty of Medicine, Southern Medical Program University Examiner Dr. Karin Pfeiffer, Michigan State University External Examiner iii Abstract Despite extensive literature on cerebral blood flow (CBF) regulation and cerebrovascular function in adults, there is very limited knowledge for the healthy child. Equally, as children’s daily sedentary behaviour increases, relationships between sedentary behaviour, physical activity, and cerebral hemodynamics are also poorly understood. This thesis aimed to determine the impact of sedentary behaviour on cerebrovascular function in healthy children. To achieve this objective four studies were conducted. An initial study (Chapter 3) explored relationships between habitual sedentary behaviour, physical activity, maturation, and CBF at rest in 78 children and adolescents (6 – 17 years), observing a lower inte…
has type: Thesis/Dissertation
date issued: 2022-11
is shown at: 10.14288/1.0421023
language: eng
degree discipline: Kinesiology
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: McManus, A. M. (Alison M.)
type: Text
identifier URI: http://hdl.handle.net/2429/82776