An investigation of cancer effect on viscoelastic properties of prostate gland via quasi-linear viscoelastic model
department or school: Applied Science, Faculty of
department or school: Mechanical Engineering, Department of
data provider: DSpace
degree campus: UBCV
creator: Helisaz, Hamed
issued: 2022-09-27T14:57:01Z
issued: 2022
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Mechanical properties of biological tissues have been shown to vary in the presence of pathological disorders. This dissertation aims to investigate the effect of cancer on the viscoelastic properties of prostate gland. We use the quasi-linear viscoelastic model to characterize the elastic and viscous characteristics of thirty-five fresh prostate glands, removed within two hours of radical prostatectomy surgery. The viscoelastic properties of normal and cancerous prostates are compared to reveal the influence of cancer grade and tumor volume on the elasticity and viscosity of prostate tissue. We first present a novel method for describing the time-dependent behavior of soft materials using one-dimensional quasi-linear viscoelastic model. Our model derives the elastic (Young’s modulus) and viscous (shear relaxation modulus) properties by analyzing the stress response after a sudden uniaxial compression. The model is validated using experimental data on the phantoms that mimic the elasticity of normal and cancerous prostate tissues. The applicability of the model for material characterization is demonstrated by introducing a procedure for obtaining the mechanical properties via indentation test. Using three-dimensional equations and pre-calculated finite element analysis, the procedure introduces a fast and straightforward approach that is superior to inverse finite element methods. We evaluate our procedure by comparing the derived properties with those obtained from uniaxial compression test, where the results show high precision (standard deviation less than 10%) and good accuracy (error less than 20%). Finally, the procedure introduced for material characterization is used to characterize the viscoelastic properties of prostate gland. We test four different locations on fresh, unfixed prostate samples and compare the properties of locations where cancer spreads with those where cancer is not present. Our data-driven results demonstrate that tumor volume increases …
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/82760
note: An Investigation of Cancer Effect on ViscoelasticProperties of Prostate Gland via Quasi-Linear ViscoelasticModelbyHamed HelisazB.Sc., Sharif University of Technology, 2014M.Sc., Sharif University of Technology, 2016A THESIS SUBMITTED IN PARTIAL FULFILLMENTOF THE REQUIREMENTS FOR THE DEGREE OFDoctor of PhilosophyinTHE FACULTY OF GRADUATE AND POSTDOCTORALSTUDIES(Mechanical Engineering)The University of British Columbia(Vancouver)September 2022© Hamed Helisaz, 2022The following individuals certify that they have read, and recommend to the Fac-ulty of Graduate and Postdoctoral Studies for acceptance, the thesis entitled:An Investigation of Cancer Effect on Viscoelastic Properties of ProstateGland via Quasi-Linear Viscoelastic Modelsubmitted by Hamed Helisaz in partial fulfillment of the requirements for the de-gree of Doctor of Philosophy in Mechanical Engineering.Examining Committee:Mu Chiao, Professor, Mechanical Engineering, UBCSupervisorMattia Bacca, Assistant Professor, Mechanical Engineering, UBCSupervisory Committee MemberAbbas Samani, Professor, Electrical and Computer Engineering, Western Univer-sityExternal ExaminerPurang Abolmaesumi, Professor, Electrical and Computer Engineering, UBCUniversity ExaminerMauricio Ponga de la Torre, Assistant Professor, Mechanical Engineering, UBCUniversity ExaminerAdditional Supervisory Committee Members:Boris Stoeber, Professor, Electrical and Computer Engineering and MechanicalEngineering, UBCSupervisory Committee MemberClarence de Silva, Professor, Mechanical Engineering, UBCSupervisory Committee MemberRyozo Nagamune, Professor, Mechanical Engineering, UBCSupervisory Committee MemberiiAbstractMechanical properties of biological tissues have been shown to vary in the pres-ence of pathological disorders. This dissertation aims to investigate the effect ofcancer on the viscoelastic properties of prostate gland. We use the quasi-linear vis-coelastic model to characterize the elastic and viscous characteristics of thirty-fivefres…
has type: Thesis/Dissertation
date issued: 2022-11
is shown at: 10.14288/1.0420751
language: eng
degree discipline: Mechanical Engineering
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Chiao, M. (Mu)
type: Text
identifier URI: http://hdl.handle.net/2429/82760