A multimodal approach for placenta characterization : towards an objective and effective pregnancy screening system
department or school: Applied Science, Faculty of
department or school: Electrical and Computer Engineering, Department of
data provider: DSpace
degree campus: UBCV
creator: Deeba, Farah
issued: 2022-07-19T16:45:03Z
issued: 2022
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Recent developments in the understanding of the role of the placenta as the ‘master regulator’ of the intra-uterine environment underline the importance of placental evaluation in pregnancy screening. The placenta plays a major role in the pathogenesis of many pregnancy complications such as preeclampsia (PE) and intrauterine growth restriction (IUGR). These complications are leading causes of maternal and perinatal mortality and morbidity, affecting as many as 34% of all pregnancies. Antenatal monitoring of placentas using non-invasive, real time imaging techniques could potentially identify sensitive biomarkers of placental health and thereby offer opportunity for early intervention enabling improved perinatal outcomes. The overarching objective of this thesis is to develop an effective and objective pregnancy screening system. To attain this objective, the first part of the thesis focused on the theoretical development of several user- and system-independent Quantitative Ultrasound (QUS) algorithms. Different approaches were adopted for improved QUS estimation by addressing the fundamental precision-resolution trade-off and effect of tissue heterogeneity. Particularly, we proposed a prior-based regularization technique, the prior being derived from ultrasound physics, and a deep learning based approach, predictUS. In the second part of the thesis, a multimodal placental imaging study, including the ultrasound, MRI, and histopathology data from 47 placentas ex vivo, was designed and conducted in collaboration with a multi-disciplinary team. The dataset from this study was utilized for the validation of the proposed QUS algorithms. Specifically, we analyzed the efficacy of different QUS parameters, including attenuation coefficient, backscatter coefficient, scatterer diameter, elasticity, and viscosity, to detect placenta-mediated diseases and clinical outcomes.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/82166
note: A Multimodal Approach for Placenta Characterization:Towards an Objective and Effective Pregnancy ScreeningSystembyFarah DeebaB.Sc. Engg., Bangladesh University of Engineering & Technology, 2013M.Sc., University of Saskatchewan, 2016A THESIS SUBMITTED IN PARTIAL FULFILLMENTOF THE REQUIREMENTS FOR THE DEGREE OFDoctor of PhilosophyinTHE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES(Electrical and Computer Engineering)The University of British Columbia(Vancouver)July 2022© Farah Deeba, 2022The following individuals certify that they have read, and recommend to the Facultyof Graduate and Postdoctoral Studies for acceptance, the dissertation entitled:A Multimodal Approach for Placenta Characterization: Towards anObjective and Effective Pregnancy Screening Systemsubmitted by Farah Deeba in partial fulfillment of the requirements for the degreeof Doctor of Philosophy in Electrical and Computer Engineering.Examining Committee:Robert Rohling, Professor, Electrical and Computer Engineering, UBCSupervisorTim Salcudean, Professor, Electrical and Computer Engineering, UBCSupervisory Committee MemberAlexander Beristain, Associate Professor, Obstetrics and Gynaecology, UBCUniversity ExaminerRaymond Ng, Professor, Computer Science, UBCUniversity ExaminerMostafa Fatemi, Professor, Physiology and Biomedical Engineering, Mayo ClinicExternal ExaminerAdditional Supervisory Committee Members:Matthew Yedlin, Associate Professor, Electrical and Computer Engineering, UBCSupervisory Committee MemberiiAbstractRecent developments in the understanding of the role of the placenta as the ‘masterregulator’ of the intra-uterine environment underline the importance of placentalevaluation in pregnancy screening. The placenta plays a major role in the pathogen-esis of many pregnancy complications such as preeclampsia (PE) and intrauterinegrowth restriction (IUGR). These complications are leading causes of maternaland perinatal mortality and morbidity, affecting as many as 34% of all pregnancies.Antenata…
has type: Thesis/Dissertation
date issued: 2022-11
is shown at: 10.14288/1.0416307
language: eng
degree discipline: Electrical and Computer Engineering
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Rohling, Robert N.
type: Text
identifier URI: http://hdl.handle.net/2429/82166