Investigating patient-reported outcomes among COVID-19 survivors : a longitudinal cohort study
department or school: Medicine, Faculty of
department or school: Population and Public Health (SPPH), School of
data provider: DSpace
degree campus: UBCV
creator: Bola, Rajan
issued: 2022-06-28T17:28:55Z
issued: 2022
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Background: Many Coronavirus Disease 2019 (COVID-19) survivors report long-term sequelae. However, few studies have measured patient-reported outcomes and compared them to those of patients who tested negative for severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). This study compares the long-term physical and mental health outcomes of patients presenting to emergency departments who tested positive for SARS-COV-2 with those who tested negative. Methods: This study enrolled consecutive eligible patients presenting to emergency departments participating in the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) between March 1st 2020 and July 14th 2021. Patients tested for SARS-COV-2 were eligible. Consecutive SARS-COV-2 positive patients were consented for follow-up, and matched with test-negative controls from the same hospital and date. The outcome measures were the Veterans RAND physical health component score (PCS) and mental health component score (MCS). The PCS and MCS of propensity score matched patients were analyzed using linear mixed effects models. Risk factors for PCS and MCS were modelled using linear regression. Results: Our cohort included 1170 SARS-COV-2 positive patients and 3716 test-negative controls. Comparing the groups, the adjusted mean difference in PCS was 0.50 (95%CI: -0.36, 1.36) and -1.01 (95%CI: -1.91, -0.11) for MCS. A World Health Organization Ordinal Outcome Score of 6-7, representing severe SARS-COV-2 disease, was the strongest predictor of PCS (β=-7.4; 95%CI: -9.8, -5.1). Prior mental health illness was the strongest predictor of MCS (β=-5.4; 95%CI: -6.3, -4.5). Conclusion: The mean PCS was similar among SARS-COV-2 positive and negative participants tested under similar circumstances, while mean MCS was worse among SARS-COV-2 positive participants. The mental health sequelae of COVID-19 should be considered when developing long-term support programs for survivors.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/81831
note: INVESTIGATING PATIENT-REPORTED OUTCOMES AMONG COVID-19 SURVIVORS: A LONGITUDINAL COHORT STUDY by Rajan Bola B.Sc., The University of British Columbia, 2020 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Population and Public Health) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) June 2022 © Rajan Bola, 2022 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, a thesis entitled: Investigating Patient-reported Outcomes Among COVID-19 Survivors: A Longitudinal Cohort Study submitted by Rajan Bola in partial fulfillment of the requirements for the degree of Master of Science in Population and Public Health Examining Committee: Dr. Corinne Hohl, Associate Professor, Department of Emergency Medicine, UBC Co-supervisor Dr. Jason Sutherland, Professor, School of Population and Public Health, UBC Co-supervisor Dr. Rachel Murphy, Assistant Professor, School of Population and Public Health, UBC Supervisory Committee Member Dr. Mieke Koehoorn, Professor, School of Population and Public Health, UBC Additional Examiner iii Abstract Background Many Coronavirus Disease 2019 (COVID-19) survivors report long-term sequelae. However, few studies have measured patient-reported outcomes and compared them to those of patients who tested negative for severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). This study compares the long-term physical and mental health outcomes of patients presenting to emergency departments who tested positive for SARS-COV-2 with those who tested negative. Methods This study enrolled consecutive eligible patients presenting to emergency departments participating in the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) between March 1st 2020 and July 14th 2021. Patients tested for SARS-COV-2 were eligible. Consecutive SARS-COV-2 positive patient…
has type: Thesis/Dissertation
date issued: 2022-11
is shown at: 10.14288/1.0415827
language: eng
degree discipline: Population and Public Health
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Hohl, Corinne M
contributor: Sutherland, Jason M.
type: Text
identifier URI: http://hdl.handle.net/2429/81831