Perinatal depression and treatment implications for mother and offspring : lessons from an animal model
department or school: Medicine, Faculty of
data provider: DSpace
degree campus: UBCV
creator: Qiu, Wansu
issued: 2022-01-05T16:32:49Z
issued: 2021
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Perinatal depression (PND) is a heterogenous disease where risk factors, symptoms, severity, treatment efficacy, and effects on children can differ depending on timing of onset. The majority of new cases occur with depression onset in the postpartum (postpartum depression; PPD). Very few people with PPD are adequately treated and even in these individuals only ~50% will reach remission with current front-line treatments of selective serotonin reuptake inhibitors (SSRIs). Inflammatory signalling has been related to antidepressant efficacy outside of the postpartum, and I investigated inflammatory mechanisms that may modulate the efficacy of fluoxetine (FLX) in the postpartum. In children, maternal SSRI treatment alters neurodevelopment, including an increased risk for autism spectrum disorder. In Chapter 4, I investigate oxytocin (OT) as a therapeutic in preadolescent offspring to ameliorate maternal treatment effects of CORT and FLX. In Chapter 2, postpartum FLX did not reduce passive coping behaviour in the dams and was commensurate with FLX induced elevations in hippocampal IL-1β levels, peripheral CXCL1 levels, and reduced plasma tryptophan concentrations. In Chapter 3, postpartum CORT treatment increased putative neurotoxic and neuroprotective metabolites within the tryptophan-metabolic pathway in dams. Maternal postpartum FLX did not reverse any postpartum CORT effects, and together with CORT, shifted the tryptophan metabolism towards neurotoxicity. In Chapter 4, maternal FLX reduced neurogenesis and IL-10, IL-13, IFN-γ expression in the hippocampus of offspring. Maternal CORT increased hippocampal neurogenesis and hippocampal IL-6:IL-10 ratio in both sexes, while periadolescent OT treatment reversed these and increased social behaviour in offspring of maternal CORT-treated dams. OT increased neurogenesis in the hippocampus of adult male offspring but not adult female offspring. Collectively, these data suggest the inefficacy of FLX long-term during the postpar…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/80511
note: PERINATAL DEPRESSION AND TREATMENT IMPLICATIONS FOR MOTHER AND OFFSPRING: LESSONS FROM AN ANIMAL MODEL by Wansu Qiu B.Sc. Hons, University of Guelph, 2016 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Neuroscience) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) December 2021 © Wansu Qiu, 2021 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the dissertation entitled: Perinatal depression and treatment implications for mother and offspring: Lessons from an animal model submitted by Wansu Qiu in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Neuroscience Examining Committee: Liisa A.M. Galea, Psychology, UBC Supervisor Joanne Weinberg, Cellular & Physiological Sciences, UBC Supervisory Committee Member Tim Oberlander, Pediatrics, UBC Supervisory Committee Member Angela Devlin, Pediatrics, UBC University Examiner Clare Beasley, Psychiatry, UBC University Examiner Additional Supervisory Committee Members: Joelle LeMoult, Psychology, UBC Supervisory Committee Member Jehannine Austin, Medical Genetics, UBC Supervisory Committee Member iii Abstract Perinatal depression (PND) is a heterogenous disease where risk factors, symptoms, severity, treatment efficacy, and effects on children can differ depending on timing of onset. The majority of new cases occur with depression onset in the postpartum (postpartum depression; PPD). Very few people with PPD are adequately treated and even in these individuals only ~50% will reach remission with current front-line treatments of selective serotonin reuptake inhibitors (SSRIs). Inflammatory signalling has been related to antidepressant efficacy outside of the postpartum, and I investigated inflammatory mechanisms that may modulate the efficacy of fluoxetine (FLX) in the postpartum. In children, maternal SS…
has type: Thesis/Dissertation
date issued: 2022-05
is shown at: 10.14288/1.0406144
language: eng
degree discipline: Neuroscience
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Galea, Liisa A. M.
type: Text
identifier URI: http://hdl.handle.net/2429/80511