The association of physical activity with resting heart rate and arterial atherosclerotic markers in patients with high lipoprotein(a)
department or school: Medicine, Faculty of
department or school: Medicine, Department of
data provider: DSpace
degree campus: UBCV
creator: Jawi, Motasim Mohammed T
issued: 2023-11-30T08:00:00Z
issued: 2021
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Patients with high levels of lipoprotein(a) (Lp[a]) have an increased risk of ischemic heart disease. Persistently elevated resting heart rate (RHR) and arterial wall thickening, two common clinical manifestations in cardiovascular disease (CVD), are known determinants of myocardial ischemia as well as predictors of future cardiovascular events. The association of improved physical activity (PA) with these ischemic heart disease risk factors in patients with high Lp(a) levels is controversial. The overall objectives of this dissertation are to provide a comprehensive investigation of RHR and early structural atherosclerotic vascular changes in patients with high Lp(a) as well as the association of PA with these two parameters. The first objective of this dissertation is to raise awareness about the harmful effects of Lp(a) (Chapter 2). I described the association between RHR and PA in primary and secondary prevention patients enrolled in the Healthy Heart Program (HHP) prevention clinic (Chapter 3). The fourth chapter aimed to evaluate the relative significance of Lp(a) as a predictor of future CVD compared with selected established CVD risk factors (Chapter 4). I also assessed the association of improved PA and RHR in HHP patients with high Lp(a) levels (Chapter 5) and explored the potential beneficial impact of improved PA on early structural atherosclerotic vascular changes in healthy subjects enrolled in the Multicultural Community Health Assessment Trial (M-CHAT) trial (Chapter 6). I showed that participants who increased their PA could reduce their RHR significantly. I also showed that male sex, Lp(a), low-density lipoprotein (LDL-C), and non-high-density lipoprotein (HDL-C) were significant independent risk factors for CVD, in decreasing order of importance. Moreover, RHR, blood pressure, and the Framingham risk score decreased significantly in HHP patients with high Lp(a) levels who improved their PA over three years. Finally, I showed that improving daily P…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/80309
note: The Association of Physical Activity with Resting Heart Rate and Arterial Atherosclerotic Markers in Patients with High Lipoprotein(a) by Motasim Mohammed T Jawi MD., King Abdulaziz University, 2010 M.Sc., Ball State University, 2015 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Experimental Medicine) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) November 2021 © Motasim Mohammed T Jawi, 2021 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the dissertation entitled: The association of physical activity with resting heart rate and endothelial atherosclerotic markers in patients with high lipoprotein(a). submitted by Motasim Jawi in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Experimental Medicine Examining Committee: Dr. Sammy Chan, Clinical Associate Professor, Department of Medicine, UBC Co-supervisor Dr. Karin Humphries, Associate Professor Emerita, Department of Medicine, UBC Co-supervisor Dr. Haydn Pritchard, Professor Emeritus, Pathology and Laboratory Medicine, UBC Supervisory Committee Member Dr. Jordan Guenette, Associate Professor, Department of Physical Therapy, UBC University Examiner Dr. Liam Brunham, Associate Professor, Department of Medicine, UBC University Examiner Additional Supervisory Committee Members: Dr. Scott Lear, Professor, Faculty of Health Sciences, SFU Supervisory Committee Member iii Abstract Patients with high levels of lipoprotein(a) (Lp[a]) have an increased risk of ischemic heart disease. Persistently elevated resting heart rate (RHR) and arterial wall thickening, two common clinical manifestations in cardiovascular disease (CVD), are known determinants of myocardial ischemia as well as predictors of future cardiovascular events. The association of improved physical activity (PA) with these ischemic …
has type: Thesis/Dissertation
date issued: 2022-05
is shown at: 10.14288/1.0404419
language: eng
degree discipline: Experimental Medicine
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Chan, Sammy H. S.
contributor: Humphries, Karin H.
type: Text
identifier URI: http://hdl.handle.net/2429/80309