Towards the detection of vulnerable atherosclerotic plaques
department or school: Applied Science, Faculty of
department or school: Engineering, School of (Okanagan)
data provider: DSpace
degree campus: UBCO
creator: Katul, Ramsey
issued: 2021-02-02T15:01:10Z
issued: 2020
related degree: Master of Applied Science - MASc
degree grantor: University of British Columbia
description: Atherosclerosis is a deadly cardiovascular disease that is one of the leading causes of mortality in North America. It slowly progresses over the course of a person’s life starting as a streak of fatty cells on the endothelial lining of arteries into a fibrous capped atherosclerotic plaque with a highly thrombotic necrotic core. It is generally asymptomatic until the plaque ruptures causing acute potentially fatal events such as stroke or myocardial infarction. A plaque’s likelihood to rupture is based on an elaborate relationship between physiological, biomechanical and geometric factors. This thesis aims develope methods to study and understand the relationship between these factors and gain a better understanding of plaque rupture. A computational study was performed and published to study the effects of the viscoelastic properties of atherosclerotic plaque on rupture. Material models were chosen to reflect the viscoelastic nature of plaque. Realistic models were obtained from medical imaging, and idealized geometries were created using shapes typically formed by necrotic cores. The computational study showed that higher heart rates led to higher stresses in the plaques. Differing viscous properties affect the stress too, as lower viscous models generated higher stress, and so more prone to rupture. The study illuminated just how limited studies like this are, and how much more there is to know. In addition to computational simulations, physical tests can help close the gap in knowledge to better treat atherosclerosis and predict plaque rupture. Arterial phantoms developed here at the Heart Valve Performance Laboratory can be utilized as they mimic the material properties of arterial tissue. They can be injected with a lipid mixture to simulate atherosclerotic plaque. The missing element is a testbed to pressurize the phantoms between a max and min at different frequencies to simulate the heart. With this testbed, a large number of arteries can be pressurized unt…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/77233
note: Towards the Detection of Vulnerable Atherosclerotic Plaques by Ramsey Katul B.A.Sc., University of British Columbia 2018 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF APPLIED SCIENCE in THE COLLEGE OF GRADUATE STUDIES (Mechanical Engineering) THE UNIVERSITY OF BRITISH COLUMBIA (Okanagan) January 2021 © Ramsey Katul, 2021 ii The following individuals certify that they have read, and recommend to The College of Graduate Studies for acceptance, a thesis/dissertation entitled: Towards the Detection of Vulnerable Atherosclerotic Plaques submitted by Ramsey Katul in partial fulfillment of the requirements for the degree of Master of Applied Science in Mechanical Engineering Examining Committee: Dr. Hadi Mohammadi, Faculty of Applied Science Supervisor Dr. Ray Taheri, Faculty of Applied Science Supervisory Committee Member Dr. Zheng Liu, Faculty of Applied Science Supervisory Committee Member Dr. Ayman El Naggar University Examiner iii Abstract Atherosclerosis is a deadly cardiovascular disease that is one of the leading causes of mortality in North America. It slowly progresses over the course of a person’s life starting as a streak of fatty cells on the endothelial lining of arteries into a fibrous capped atherosclerotic plaque with a highly thrombotic necrotic core. It is generally asymptomatic until the plaque ruptures causing acute potentially fatal events such as stroke or myocardial infarction. A plaque’s likelihood to rupture is based on an elaborate relationship between physiological, biomechanical and geometric factors. This thesis aims develope methods to study and understand the relationship between these factors and gain a better understanding of plaque rupture. A computational study was performed and published to study the effects of the viscoelastic properties of atherosclerotic plaque on rupture. Material models were chosen to reflect the viscoelastic nature of plaque. Realistic models were obtained from medical i…
has type: Thesis/Dissertation
date issued: 2021-02
is shown at: 10.14288/1.0395804
language: eng
degree discipline: Mechanical Engineering
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-ShareAlike 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-sa/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/77233