How mental fatigue influences neurovascular coupling in post-concussion syndrome : a preliminary pilot study
department or school: Health and Social Development, Faculty of (Okanagan)
department or school: Health and Exercise Sciences, School of (Okanagan)
data provider: DSpace
degree campus: UBCO
creator: Tapsell, Liam Connor
issued: 2021-01-18T19:04:52Z
issued: 2021
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Introduction: Although most concussions have symptoms only lasting a few days, some leave impact for months or more, becoming post-concussion syndrome (PCS). With PCS, there can be reduced capacity of mental processes, this is called mental fatigue. It is unknown how mental fatigue manifests in the brain, which limits treatment to those affected. It is possible that the relationship between neural activation and blood flow could provide insight. Methods: 4 participants completed a questionnaire on their concussion history and symptoms. They then completed a self-report survey on how mentally fatigued they felt, as well completing a transcranial Doppler (ultrasound) measure of the middle cerebral artery (MCA) and posterior cerebral artery (PCA) response to stimuli in and simple reaction time (SRT) before and after a 45-60-minute task designed to induce mental fatigue. Results: It was found that changes in mental fatigue questionnaire responses had a strong, positive correlation with both number of PCS symptoms (R=0.99) and symptom severity (R=0.94). Higher levels of mental fatigue were strongly associated with lower time to cerebral blood flow (CBF) peak (PCA=-0.75, MCA=-0.72) and lower increases in CBF from rest to peak stimulation (PCA=-0.67, MCA=-0.56). Higher changes in mental fatigue were strongly associated with worse SRT in both a visual task (R=0.52) and an auditory task (0.98). Discussion: These preliminary data are the first to indicate a physiological manifestation of mental fatigue as a PCS symptom, improving our understanding of the symptom. Interventions for physiological symptoms could be adapted to improve PCS-based mental fatigue.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/77139
note: HOW MENTAL FATIGUE INFLUENCES NEUROVASCULAR COUPLING IN POST-CONCUSSION SYNDROME: A PRELIMINARY PILOT STUDY by Liam Connor Tapsell B.Sc., The University of Western Australia, 2017 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in The College Of Graduate Studies (Health and Exercise Sciences) THE UNIVERSITY OF BRITISH COLUMBIA (Okanagan) January 2021 © Liam Connor Tapsell, 2021 ii The following individuals certify that they have read, and recommend to the College of Graduate Studies for acceptance, a thesis/dissertation entitled: HOW MENTAL FATIGUE INFLUENCES NEUROVASCULAR COUPLING IN POST-CONCUSSION SYNDROME: A PRELIMINARY PILOT STUDY submitted by Liam Connor Tapsell in partial fulfillment of the requirements of the degree of Master of Science. Dr. Paul van Donkelaar, Faculty of Health and Social Development/ School of Health and Exercise Sciences ___________________________________________________________________Supervisor Dr. Brian Dalton, Faculty of Health and Social Development/ School of Health and Exercise Sciences ___________________________________________________________________Supervisory Committee Member Dr. Chris McNeil, Faculty of Health and Social Development/ School of Health and Exercise Sciences ___________________________________________________________________Supervisory Committee Member Dr. Kathryn Schnieder, University of Calgary ___________________________________________________________________External Examiner iii Abstract Introduction: Although most concussions have symptoms only lasting a few days, some leave impact for months or more, becoming post-concussion syndrome (PCS). With PCS, there can be reduced capacity of mental processes, this is called mental fatigue. It is unknown how mental fatigue manifests in the brain, which limits treatment to those affected. It is possible that the relationship between neural activation and blood flow could provide insight. Methods: 4 participants comp…
has type: Thesis/Dissertation
date issued: 2021-02
is shown at: 10.14288/1.0395650
language: eng
degree discipline: Health and Exercise Sciences
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/77139