The effects of atorvastatin on testosterone levels in males and females : a systematic review and meta-analysis
department or school: Medicine, Faculty of
department or school: Anesthesiology, Pharmacology and Therapeutics, Department of
data provider: DSpace
degree campus: UBCV
creator: Shawish, MHD Ismail
issued: 2020-10-01T22:03:01Z
issued: 2020
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Background: Statins are one of the most prescribed classes of drugs worldwide. Atorvastatin, the most prescribed statin, is currently used to treat conditions such as hypercholesterolemia and dyslipidemia. Testosterone and other androgens play important roles in biological functions. A potential reduction in androgens levels caused by atorvastatin might cause negative effects except for conditions such as polycystic ovary syndrome (PCOS), where reduction of excessive levels of androgens is potentially beneficial. Objectives: To quantify the magnitude of the effects of atorvastatin as compared to placebo or no treatment on total testosterone, free testosterone, sex hormone binding globin (SHBG), androstenedione, dehydroepiandrosterone sulfate (DHEAS) concentrations, free androgen index (FAI), and withdrawal due to adverse effects (WDAEs). Methods: We searched major databases (CENTRAL, MEDLINE, EMBASE) and other sources for randomized controlled trials (RCTs) comparing atorvastatin with placebo or no treatment on testosterone levels in males and females. Two authors independently screened the citations, extracted the data and assessed the quality of the included studies. We used mean difference with 95% confidence interval to report effect size of continuous outcomes and a fixed effect model to combine the effect sizes across studies, and risk ratio to report effect size of the dichotomous outcome (WDAEs). iv Results: We included six RCTs involving 265 participants. Participants in two of the studies were male with normal or mild dyslipidemia (N=140). Participants in four of the studies were female with PCOS (N=125). Compared to placebo, atorvastatin had no significant effect on total testosterone levels (MD -0.20 [-0.77, 0.37] nmol/L in males. Atorvastatin may reduce total testosterone, FAI, androstenedione, and DHEAS in females by -0.27 (-0.50, -0.04) nmol/L, -2.59 (-3.62, -1.57), -1.37 nmol/L (-2.26, -0.49), and -0.64 μmol/l (-1.12, -0.16), respectively. Furthermor…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/76235
note: The Effects of Atorvastatin on Testosterone Levels in Males and Females: A Systematic Review and Meta-analysis by MHD Ismail Shawish B. Pharm, Damascus University, 2012 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF Master of Science in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Pharmacology and Therapeutics) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) September 2020 © MHD Ismail Shawish, 2020 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, a thesis entitled: The Effects of Atorvastatin on Testosterone Levels in Males and Females: A Systematic Review and Meta-analysis submitted by MHD Ismail Shawish in partial fulfillment of the requirements for the degree of Master of Science in Pharmacology and Therapeutics Examining Committee: Prof. James M. Wright, Anesthesiology, Pharmacology & Therapeutics Supervisor Assistant Prof. Vijaya Musini, Anesthesiology, Pharmacology & TherapeuticsSupervisory Committee Member Prof. Ismail Laher, Anesthesiology, Pharmacology & TherapeuticsSupervisory Committee Member iii Abstract Background: Statins are one of the most prescribed classes of drugs worldwide. Atorvastatin, the most prescribed statin, is currently used to treat conditions such as hypercholesterolemia and dyslipidemia. Testosterone and other androgens play important roles in biological functions. A potential reduction in androgens levels caused by atorvastatin might cause negative effects except for conditions such as polycystic ovary syndrome (PCOS), where reduction of excessive levels of androgens is potentially beneficial. Objectives: To quantify the magnitude of the effects of atorvastatin as compared to placebo or no treatment on total testosterone, free testosterone, sex hormone binding globin (SHBG), androstenedione, dehydroepiandrosterone sulfate (DHEAS) concentrations, free androgen index (FAI), and withdrawal due to adverse effect…
has type: Thesis/Dissertation
date issued: 2020-11
is shown at: 10.14288/1.0394589
language: eng
degree discipline: Pharmacology and Therapeutics
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/76235