Effect of alcohol on blood pressure : a systematic review and meta-analysis
department or school: Medicine, Faculty of
department or school: Anesthesiology, Pharmacology and Therapeutics, Department of
data provider: DSpace
degree campus: UBCV
creator: Tasnim, Sara
issued: 2019-10-21T17:23:15Z
issued: 2019
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Background: Alcohol is consumed by over 2 billion people worldwide. It is a common substance of abuse and can lead to more than 200 disorders including hypertension. Alcohol has both acute and chronic effects on blood pressure. This systematic review aimed to quantify the acute effect of different doses of alcohol on blood pressure (BP) and heart rate (HR) over time in the adult with both normal and raised blood pressure. We classified doses of alcohol into low (≤14 g alcohol), medium (>14g and ≤30g alcohol) and high (>30 g alcohol) based on the definition by Canadian Centre on Substance Use and Addiction. Objective: To quantify the magnitude of effect of acute alcohol consumption on blood pressure and heart rate in adults (≥18 years) during three different time periods: early, intermediate, and late. Method: We searched major databases (CENTRAL, MEDLINE, EMBASE) and other sources for randomized placebo-controlled trials (RCTs) comparing the effect of single-dose of alcohol with placebo on BP or HR in adults. Two authors independently extracted the data and assessed the quality of the studies. We used mean difference with 95% confidence interval to report effect size of outcome measures and a fixed effect model to combine the effect sizes across studies. Results: We included 32 RCTs involving 767 participants. Most of the study participants were healthy males (N=642) with a mean age of 33 years. Compared to placebo, low dose alcohol consumption had no significant early effect on BP but increased HR by 5 beats per minute (bpm). Effect of medium dose of alcohol on BP during the early period was -5.6/-4.0 mmHg and increase in HR was 4.6 bpm. The effect of high dose alcohol on mmHg BP was biphasic: early (-3.5/-1.9) intermediate (-3.7/-1.6) and late (3.7/2.4). HR in bpm was increased at all time periods: early 5.8, intermediate 6.2 and late 2.7. Conclusion: Compared to placebo alcohol causes a decrease in BP and increase in HR during the early and intermediate time peri…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/72008
note: Effect of Alcohol on Blood Pressure: A Systematic Review and Meta-analysis by Sara Tasnim B. Pharm. Professional, University of Dhaka, 2016 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF Master of Science in The Faculty of Graduate and Postdoctoral Studies (Pharmacology and Therapeutics) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) October 2019 ©Sara Tasnim, 2019 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, a thesis entitled: Effect of Alcohol on Blood Pressure: A Systematic Review and Meta-analysis submitted by Sara Tasnim in partial fulfillment of the requirements for the degree of Master of Science in Pharmacology and Therapeutics Examining Committee: James M. Wright, Anesthesiology, Pharmacology and Therapeutics Supervisor Kenneth Bassett, Anesthesiology, Pharmacology and Therapeutics Supervisory Committee Member Vijaya Musini, Anesthesiology, Pharmacology and Therapeutics Supervisory Committee Member iii Abstract Background: Alcohol is consumed by over 2 billion people worldwide. It is a common substance of abuse and can lead to more than 200 disorders including hypertension. Alcohol has both acute and chronic effects on blood pressure. This systematic review aimed to quantify the acute effect of different doses of alcohol on blood pressure (BP) and heart rate (HR) over time in the adult with both normal and raised blood pressure. We classified doses of alcohol into low (≤14 g alcohol), medium (>14g and ≤30g alcohol) and high (>30 g alcohol) based on the definition by Canadian Centre on Substance Use and Addiction. Objective: To quantify the magnitude of effect of acute alcohol consumption on blood pressure and heart rate in adults (≥18 years) during three different time periods: early, intermediate, and late. Method: We searched major databases (CENTRAL, MEDLINE, EMBASE) and other sources for randomized placebo-controlled trials (RC…
has type: Thesis/Dissertation
date issued: 2019-11
is shown at: 10.14288/1.0384576
language: eng
degree discipline: Pharmacology and Therapeutics
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/72008