Custom template design and manufacture automation for interstitial gynecological brachytherapy
department or school: Arts and Sciences, Irving K. Barber School of (Okanagan)
department or school: Computer Science, Mathematics, Physics and Statistics, Department of (Okanagan)
data provider: DSpace
degree campus: UBCO
creator: Kudla-Hooper, Michael William
issued: 2019-09-30T15:48:46Z
issued: 2019
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Treatment of vaginal and post-operative locally recurrent endometrial cancers is challenging with currently available commercial High Dose Rate Brachytherapy (HDRBT) applicators. A novel concept, the patient specific cylinder template (PSCT) has been developed to address these challenges. The PSCT is produced in-house using an automated design and 3D printing workflow, which utilizes custom scripts interfacing with both treatment planning and modelling software to create 3D models for 3D printing PSCTs. The workflow and template were tested using images and treatment plans for two patients previously treated using a combination of vaginal cylinder and interstitial catheters. New catheter arrangements were planned using geometries achievable with a PSCT. A template was then modelled and 3D printed, a mock insertion was completed in a gel phantom, and a post-insertion CT scan was completed. These images were registered to the patient images, the final catheter positions were digitized, and a final plan was created. Inserted re-optimized treatment plans demonstrated competitive tumour coverage, while maintaining doses to organs at risk, within acceptable limits. Catheters were inserted with sufficient accuracy to achieve a plan clinically equivalent to the pre-insertion plan, with much greater ease as compared to freehand or perineal template methods. The PSCT, while requiring further development and clinical trials, stands to be a preferable alternative to current HDRBT methods for patients with vaginal and post-operative locally recurrent endometrial cancers.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/71805
note: CUSTOM TEMPLATE DESIGN AND MANUFACTURE AUTOMATION FOR INTERSTITIAL GYNECOLOGICAL BRACHYTHERAPY by Michael William Kudla-Hooper B.Sc., Physics, Walla Walla University, 2014 BSE, Mechanical Engineering, Walla Walla University, 2014 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE COLLEGE OF GRADUATE STUDIES (Medical Physics) THE UNIVERSITY OF BRITISH COLUMBIA (Okanagan) September 2019 © Michael William Kudla-Hooper, 2019 ii The following individuals certify that they have read, and recommend to the College of Graduate Studies for acceptance, a thesis/dissertation entitled: Custom Template Design and Manufacture Automation for Interstitial Gynecological Brachytherapy submitted by Michael William Kudla-Hooper in partial fulfillment of the requirements of the degree of Master of Science. Deidre Batchelar, IKBSAS - Physics & BC Cancer Kelowna Supervisor Andrew Jirasek, IKBSAS - Physics Supervisory Committee Member Danielle Anderson, IKBSAS - Physics & BC Cancer Kelowna Supervisory Committee Member Ingrid Spadinger, UBC Faculty of Medicine & BC Cancer Vancouver University Examiner iii Abstract Treatment of vaginal and post-operative locally recurrent endometrial cancers is challenging with currently available commercial High Dose Rate Brachytherapy (HDRBT) applicators. A novel concept, the patient specific cylinder template (PSCT) has been developed to address these challenges. The PSCT is produced in-house using an automated design and 3D printing workflow, which utilizes custom scripts interfacing with both treatment planning and modelling software to create 3D models for 3D printing PSCTs. The workflow and template were tested using images and treatment plans for two patients previously treated using a combination of vaginal cylinder and interstitial catheters. New catheter arrangements were planned using geometries achievable with a PSCT. A template was then modelled and 3D printed, a mock insertion was completed …
has type: Thesis/Dissertation
date issued: 2019-11
is shown at: 10.14288/1.0381040
language: eng
degree discipline: Medical Physics
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/71805