Effects of prenatal alcohol exposure on social behavior neurobiology in rats
department or school: Medicine, Faculty of
data provider: DSpace
degree campus: UBCV
creator: Holman, Parker J.
issued: 2020-08-31T07:00:00Z
issued: 2019
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Estimates indicate a 1-5% prevalence of Fetal Alcohol Spectrum Disorders (FASD) among American children, making prenatal alcohol exposure (PAE) a leading cause of developmental disability in North America. Among the cognitive, physiological and behavioral impairments associated with PAE in the clinical/pre-clinical literature, lifelong social behavior deficits serve as a unifying feature across the entire spectrum. Impaired social behavior in individuals with FASD has widespread implications for function in other domains and may contribute to difficulties within school, social rejection, trouble with the law, and later mental health problems. Importantly, early-life adversity (ELA) can also modulate social behavior development, and individuals with PAE are more likely to experience ELA. However, few studies have assessed the interactive effects of these two insults on social behavior development. Maturational changes associated with adolescence have significant consequences for social behavior development, making adolescence a unique period of increased vulnerability to social behavior dysfunction. My dissertation research focuses on establishing a comprehensive neurobehavioral profile of adolescent social behavior in a rat model of PAE. Our assessments of play behavior, social preference and recognition memory, as well as central oxytocin and vasopressin systems, critical modulators of social behavior function, indicate PAE impairs adolescent social behavior – especially with increasing complexity of the social context – and behavioral impairments are associated with altered neural activity and development of the oxytocin/vasopressin systems. Specifically, we found that PAE disrupts sustained play bouts with unexposed playmates, impairs social recognition memory – particularly in males – and alters oxytocin receptor expression and neural activity (c-fos expression) in limbic and forebrain regions important for social behavior function. Moreover, ELA generally exace…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/71374
note: EFFECTS OF PRENATAL ALCOHOL EXPOSURE ON SOCIAL BEHAVIOR NEUROBIOLOGY IN RATS by Parker J. Holman BS, University of Oklahoma, 2006, MS, University of Oklahoma, 2011 MSEd, CUNY: Lehman College, 2012 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Neuroscience) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) August 2019 © Parker J. Holman, 2019 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the dissertation entitled: submitted by in partial fulfillment of the requirements for the degree of in Examining Committee: Supervisor Supervisory Committee Member Supervisory Committee Member University Examiner University Examiner Additional Supervisory Committee Members: Supervisory Committee Member Supervisory Committee Member Effects of prenatal alcohol exposure on social behavior neurobiology in ratsParker J. HolmanDoctor of PhilosophyNeuroscienceDr. Joanne WeinbergDr. Liisa GaleaDr. Kimberly Schonert-ReichlDr. Amori Yee MikamiDr. Catharine RankinDr. Ruth Grunauiii Abstract Estimates indicate a 1-5% prevalence of Fetal Alcohol Spectrum Disorders (FASD) among American children, making prenatal alcohol exposure (PAE) a leading cause of developmental disability in North America. Among the cognitive, physiological and behavioral impairments associated with PAE in the clinical/pre-clinical literature, lifelong social behavior deficits serve as a unifying feature across the entire spectrum. Impaired social behavior in individuals with FASD has widespread implications for function in other domains and may contribute to difficulties within school, social rejection, trouble with the law, and later mental health problems. Importantly, early-life adversity (ELA) can also modulate social behavior development, and individuals with PAE are more likely to experience ELA. However, few studies have…
has type: Thesis/Dissertation
date issued: 2019-09
is shown at: 10.14288/1.0380508
language: eng
degree discipline: Neuroscience
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/71374