Rigid registration of 3D ultrasound images and computed tomography images for permanent breast seed implant brachytherapy treatment planning
department or school: Arts and Sciences, Irving K. Barber School of (Okanagan)
department or school: Computer Science, Department of
data provider: DSpace
degree campus: UBCO
creator: Zhang, Xiaoying
issued: 2019-08-07T15:29:54Z
issued: 2019
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Purpose: The purpose of this work is to further develop and to validate a prototype three-dimensional ultrasound (3DUS) system for permanent breast seed implant (PBSI) planning procedure. PBSI is a novel brachytherapy technique for early-stage breast cancer patients. Palladium-103 seeds are planned around the seroma cavity and implanted through the guidance of a needle implant template. Currently, PBSI plans are made based on computed tomography (CT) images, while the delivery is guided under freehand 2D ultrasound (US) images in the operating room. The difference on seroma visualization on CT and US complicates the interpretation of the plan during the delivery. A prototype PBSI 3DUS system has been developed and 3DUS images are desired for improved visualization in PBSI treatment planning. Materials and Methods: The PBSI 3DUS system includes a motorized scanner that drives a 2D US probe during scanning. An encoded mechanical arm is mounted on the scanner and tracks the location of the needle implant template, and the template can be then registered into the 3DUS imaging volume for visual guidance. A method was developed to rigidly register 3DUS images with CT images through a point-based registration. A 3D-printed model was made to provide visible landmarks in both imaging volumes. Gel breast phantoms were constructed to test the registration feasibility and accuracy. Results: A 3D-printed model with eight landmarks ranging over 6 cm in three dimensions was adopted for 3DUS-CT rigid registration process. The registration was performed on gel breast phantoms, with the 3DUS scanner oriented in a 40 range of lateral orientation. The average registration error was (1.9 ± 0.8) mm. The maximum error in 25 3DUS-CT registration trials was 4.6 mm, and 19 out of 25 (76%) trials had a registration error less than 2 mm. Conclusions: This work facilitated the clinical implementation of the PBSI 3DUS system. The 3DUS system was commissioned and a clinical quality assurance (QA)…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/71253
note: Rigid Registration of 3D Ultrasound Images andComputed Tomography Images for PermanentBreast Seed Implant Brachytherapy TreatmentPlanningbyXiaoying ZhangB.Sc., Fudan University, 2017A THESIS SUBMITTED IN PARTIAL FULFILLMENTOF THE REQUIREMENTS FOR THE DEGREE OFMASTER OF SCIENCEinThe College of Graduate Studies(Medical Physics)THE UNIVERSITY OF BRITISH COLUMBIA(Okanagan)August 2019© Xiaoying Zhang, 2019The following individuals certify that they have read, and recommend to the College of GraduateStudies for acceptance, a thesis/dissertation entitled:RIGID REGISTRATION OF 3D ULTRASOUND IMAGES AND COMPUTED TOMOGRAPHY IM-AGES FOR PERMANENT BREAST SEED IMPLANT BRACHYTHERAPY TREATMENT PLANNINGsubmitted by XIAOYING ZHANG in partial fulfilment of the requirements of the degree of Masterof ScienceDr. Michelle Hilts, I. K. Barber School of Arts & SciencesSupervisorDr. Andrew Jirasek, I. K. Barber School of Arts & SciencesSupervisory Committee MemberDr. Deidre Batchelar, I. K. Barber School of Arts & SciencesSupervisory Committee MemberDr. Hadi Mohammadi, School of EngineeringUniversity ExamineriiAbstractPurpose: The purpose of this work is to further develop and to validate a prototype three-dimensionalultrasound (3DUS) system for permanent breast seed implant (PBSI) planning procedure. PBSI isa novel brachytherapy technique for early-stage breast cancer patients. Palladium-103 seeds areplanned around the seroma cavity and implanted through the guidance of a needle implant template.Currently, PBSI plans are made based on computed tomography (CT) images, while the deliveryis guided under freehand 2D ultrasound (US) images in the operating room. The difference onseroma visualization on CT and US complicates the interpretation of the plan during the delivery.A prototype PBSI 3DUS system has been developed and 3DUS images are desired for improvedvisualization in PBSI treatment planning.Materials and Methods: The PBSI 3DUS system includes a motorized scanner that drives a 2DUS prob…
has type: Thesis/Dissertation
date issued: 2019-09
is shown at: 10.14288/1.0380347
language: eng
degree discipline: Medical Physics
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/71253