Bilateral measurement of pelvic floor muscle dysfunction in females with lower urinary tract symptoms using near infrared spectroscopy
department or school: Medicine, Faculty of
department or school: Medicine, Department of
data provider: DSpace
degree campus: UBCV
creator: Deegan, Emily Grace
issued: 2019-03-20T17:35:37Z
issued: 2019
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Introduction and Objective: Near infrared spectroscopy (NIRS) is a noninvasive method of measuring oxygen recovery kinetics in skeletal muscle. NIRS detects changes in oxygenated (O₂Hb) and deoxygenated (HHb) hemoglobin in response to exercise, to provide interpretation of muscular capacity to restore incurred oxygen debt. Assessment of pelvic floor muscle (PFM) function is central to managing urinary incontinence (UI) and lower urinary tract symptoms (LUTS) but currently lacks oxygen kinetic parameters. This project aims to develop a NIRS probe that measures oxygen kinetics of bilateral PFM in females with UI/LUTS (cases) related to altered pelvic innervation compared to continent controls. Methods: A transvaginal NIRS prototype to detect bilateral PFM was developed. The vaginal NIRS probe monitored female volunteers during sustained PFM contraction (SMVC). O₂Hb, HHb and HbDiff (O₂Hb-HHb) allowed measurement of oxygen kinetics unique to bilateral PFM. Oxygen recovery kinetics determined by HbDiff half recovery time (½RT). PFM manometry assessed SMVC peak and average cmH₂O. Home-based 8-week PFM therapy (PFMT) intervention was performed by both participant groups and an exercise diary measured adherence, determined as total percentage of volume and frequency. Results: Observational NIRS findings demonstrated typical hemodynamic and ½RT responses in controls. Case group demonstrated atypical findings consistent with impaired muscle function. NIRS found quicker ½RT for controls (7.87 vs 38.03 seconds, p 0.01). Manometer detected greater PFM strength and endurance in controls (SMVC peak 35 vs 13 cmH2O, p <0.01, SMVC average 23 vs 10 cmH₂O, p 0.02). Intra-group improvements of PFM NIRS and manometer variables after PFMT were not determined. Post-PFMT ½RT in cases was highly correlated to SMVC peak and average cmH2O (r -0.83 and r -0.82, respectively). High adherence of PFMT frequency demonstrated in cases, 78%, which correlated to SMVC peak and average cmH₂O (rs 0.78 an…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/68995
note: BILATERAL MEASUREMENT OF PELVIC FLOOR MUSCLE DYSFUNCTION IN FEMALES WITH LOWER URINARY TRACT SYMPTOMS USING NEAR INFRARED SPECTROSCOPY by Emily Grace Deegan B.A., The University of Western Ontario, 2009 B.Sc.N., The University of Toronto, 2011 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Experimental Medicine) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) March 2019 © Emily Grace Deegan, 2019 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, a thesis/dissertation entitled: Bilateral measurement of pelvic floor muscle dysfunction in females with lower urinary tract symptoms using near infrared spectroscopy submitted by Emily Deegan in partial fulfilment of the requirements for the degree Master of Science in Experimental Medicine Examining Committee: Lynn Stothers, Urological Sciences Supervisor Andrew Macnab, Urological Sciences Supervisory Committee Member Supervisory Committee Member Gary Gray, Division of Urology Additional Examiner Additional Supervisory Committee Members: Tania Lam, School of Kinesiology Supervisory Committee Member iii Abstract Introduction and Objective: Near infrared spectroscopy (NIRS) is a noninvasive method of measuring oxygen recovery kinetics in skeletal muscle. NIRS detects changes in oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin in response to exercise, to provide interpretation of muscular capacity to restore incurred oxygen debt. Assessment of pelvic floor muscle (PFM) function is central to managing urinary incontinence (UI) and lower urinary tract symptoms (LUTS) but currently lacks oxygen kinetic parameters. This project aims to develop a NIRS probe that measures oxygen kinetics of bilateral PFM in females with UI/LUTS (cases) related to altered pelvic innervation compared to continent controls. Methods: A transvaginal NIRS protot…
has type: Thesis/Dissertation
date issued: 2019-05
is shown at: 10.14288/1.0377236
language: eng
degree discipline: Experimental Medicine
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/68995