Insights into the effect of blood pressure and pregnancy on the PPG signal
department or school: Applied Science, Faculty of
department or school: Biomedical Engineering, School of
data provider: DSpace
degree campus: UBCV
creator: Ramos Macias, Barbara Monserrat
issued: 2018-12-20T17:08:08Z
issued: 2018
related degree: Master of Applied Science - MASc
degree grantor: University of British Columbia
description: Introduction: Hypertension in pregnancy, characterized by high blood pressure, is one of the three most common causes of maternal death. Photoplethysmography (PPG) is a portable, non-invasive and low-cost technique, which might have the potential to detect hypertension in pregnancy along with measuring three vital signs: oxygen saturation, heart rate, and respiratory rate. Currently, efforts have been made to estimate blood pressure and detect hypertension with the PPG signal. Objectives: The primary objective of this study is to describe the effect of pregnancy and blood pressure on the PPG signal. Methods: We calculated the average pulse per month of gestational age from 5,072 PPG signals of normotensive women to create a visual representation of a normal pregnancy effect on the PPG morphology. We fitted a linear model using the gestational age, blood pressure, and their interaction to predict PPG features. The PPG features were extracted from 11,412 PPG signals of pregnant women. The PPG features were calculated using four algorithms developed to locate the: dicrotic notch, diastolic peak, systolic peak, start of the pulse, and second derivative waves. Results: We observed PPG morphology changes based on the gestational age in normal pregnancy. The association with blood pressure described in the literature for non-pregnant subjects of some PPG features such as heart rate can change in pregnancy based on the gestational age. The obtained results of the four algorithms are: 1) pulse location algorithm with an accuracy of 97.67% and 98.1% for the start of the pulse and systolic peak location, respectively; 2) pulse verification algorithm improved pulse location positive predictivity; 3) equal accuracy between the ʻaʼ and ʻbʼ waves and the pulses location; and 4) reliable dicrotic notch, diastolic peak and ʻeʼ location based on the comparison with a high-performance dicrotic notch algorithm and visual inspection. Conclusion: The normal cardiovascular changes seen du…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/68114
note: Insights into the effect of bloodpressure and pregnancy on the PPGsignalbyBa´rbara Monserrat Ramos Mac´ıasB.Sc., The University of Guadalajara, 2015A THESIS SUBMITTED IN PARTIAL FULFILLMENT OFTHE REQUIREMENTS FOR THE DEGREE OFMASTER OF APPLIED SCIENCEinThe Faculty of Graduate and Postdoctoral Studies(Biomedical Engineering)THE UNIVERSITY OF BRITISH COLUMBIA(Vancouver)December 2018c© Ba´rbara Monserrat Ramos Mac´ıas 2018The following individuals certify that they have read, and recommend tothe Faculty of Graduate and Postdoctoral Studies for acceptance, the thesisentitled:Insights into the effect of blood pressure and pregnancy on the PPG signalsubmitted by Ba´rbara Monserrat Ramos Mac´ıas in partial fulfillment of therequirements for the degree of Master of Applied Science inBiomedical EngineeringExamining committee:Guy Albert Dumont, Electrical and computer engineeringSupervisorJohn Mark Ansermino, Anesthesiology, pharmacology and therapeuticsCo-SupervisorPhilippe Kruchten, Electrical and computer engineeringChair nomineeiiAbstractIntroduction: Hypertension in pregnancy, characterized by high blood pres-sure, is one of the three most common causes of maternal death. Photo-plethysmography (PPG) is a portable, non-invasive and low-cost technique,which might have the potential to detect hypertension in pregnancy alongwith measuring three vital signs: oxygen saturation, heart rate, and respi-ratory rate. Currently, efforts have been made to estimate blood pressureand detect hypertension with the PPG signal.Objectives: The primary objective of this study is to describe the effectof pregnancy and blood pressure on the PPG signal.Methods: We calculated the average pulse per month of gestational agefrom 5,072 PPG signals of normotensive women to create a visual represen-tation of a normal pregnancy effect on the PPG morphology. We fitted alinear model using the gestational age, blood pressure and their interactionto predict PPG features. The PPG features were extracted fro…
has type: Thesis/Dissertation
date issued: 2019-02
is shown at: 10.14288/1.0375800
language: eng
degree discipline: Biomedical Engineering
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/68114