Muscle fatigue at high-altitude : acute and chronic adaptations at the central and peripheral level
department or school: Health and Social Development, Faculty of (Okanagan)
department or school: Health and Exercise Sciences, School of (Okanagan)
data provider: DSpace
degree campus: UBCO
creator: Luca, Ruggiero
issued: 2018-12-07T16:41:49Z
issued: 2018
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: It is known that acute hypoxia induces a reduction in performance, that Lowlanders acclimatize to hypoxia after prolonged exposure, and that Sherpa outperform Lowlanders at high-altitude. However, research on adaptations from short- and long-term chronic exposure to hypoxia is scarce. This is due to the challenges of bringing Lowlanders to high-altitude as well as the limited opportunity to study high-altitude dwellers in their native environment. Hence, the purpose of this dissertation is to broaden the knowledge of short- and long-term neuromuscular adaptations to residency at high-altitude (i.e. chronic hypoxia) and to assess how these adaptations impact performance and muscle fatigue in the high-altitude environment. Four research studies have been included in the present thesis. Studies 1 and 2 investigate how acute hypoxia and acclimatization to high-altitude affect fatigue in Lowlanders, covering cerebral and spinal mechanisms in study 1, and muscular (i.e. peripheral) mechanisms in study 2. In studies 3 and 4, the spectrum of acclimatization considered was widened, and neuromuscular fatigue at high-altitude was compared between Lowlanders (1-2 weeks of chronic hypoxia) and Sherpa (a lifetime of altitude-related adaptations) for the brain-to-muscle pathway (study 3) and at the muscular level (study 4). Findings from this dissertation will be beneficial to enhance the current knowledge of the efficacy of acclimatization to hypoxia in Lowlanders, and to devise strategies to maintain performance in individuals working or training at high-altitude.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/67990
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has type: Thesis/Dissertation
date issued: 2019-02
is shown at: 10.14288/1.0375645
language: eng
degree discipline: Interdisciplinary Studies
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/67990