Cerebrovascular and peripheral vascular regulation : role of oxidative stress
department or school: Graduate Studies, College of (Okanagan)
data provider: DSpace
degree campus: UBCO
creator: Hansen, Alexander Bradley
issued: 2017-10-18T22:02:25Z
issued: 2017
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Oxidative stress is ultimately determined by the balance between pro- (e.g. free radicals) and antioxidants (e.g. vitamin C). The purpose of this thesis was to examine the role and effect of a combined mixture of oral antioxidants (vitamin C, E, and alpha-lipoic acid) on peripheral and cerebrovascular regulation at both sea-level (344m; n = 11 participants) and at high altitude (5050m; n=10) where oxidative stress is markedly elevated. In a randomized and double-blinded design, flow-mediated dilation, cardiorespiratory, cerebral blood flow, and CO₂ and hypoxic cerebrovascular reactivity tests were conducted before and 90 mins following antioxidants (vitamin C, E, and alpha-lipoic acid) or a placebo control, previous work has shown antioxidant levels increased in blood plasma after 90 mins of ingestion. Following 10-12 days at 5050m, in a similar design, flow-mediated dilation, cardiorespiratory, and resting cerebral blood flow tests were obtained. The primary findings were: 1) antioxidants did not alter flow-mediated dilation, resting cerebral blood flow, cerebrovascular reactivity to CO₂ or hypoxia at sea-level; 2) similarly, at high-altitude (Nepal, 5050m), antioxidants did not alter flow-mediated dilation or resting cerebral blood flow. In conclusion, this study highlights that at both sea-level and high-altitude, acute oral administration of antioxidants does not alter FMD or cerebrovascular reactivity to CO₂ or hypoxia. Nevertheless, continued exploration of this methodology is recommended, especially in the form of more chronic dosing of antioxidants in various pathologies (e.g., chronic pulmonary obstructed disease, diabetes, coronary artery disease) who present with excessive oxidative stress and reductions in both antioxidant capacity and vascular function. This study received ethical approval from the University of British Columbia Clinical Research Ethics Board (ID: H16-00101). This research was supported by a NSERC Discovery grant and Canadian Research C…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/63341
note: Cerebrovascular and Peripheral Vascular Regulation: Role of Oxidative Stress by Alexander Bradley Hansen B.H.K., The University of British Columbia, 2015 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE COLLEGE OF GRADUATE STUDIES (Interdisciplinary Studies) THE UNIVERSITY OF BRITISH COLUMBIA (Okanagan) October 2017 © Alexander Bradley Hansen, 2017 The following individuals certify that they have read, and recommend to the College of Graduate Studies for acceptance, a thesis/dissertation entitled: Cerebrovascular and Peripheral Vascular Regulation: Role of Oxidative Stress submitted by Alexander Bradley Hansen in partial fulfillment of the requirements of the degree of Master of Science. Dr. Philip Ainslie, PhD, Faculty of Human Kinetics, UBC Okanagan Supervisor Dr. Alison McManus, PhD, Faculty of Human Kinetics, UBC Okanagan Supervisory Committee Member Dr. Glen Foster, PhD, Faculty of Human Kinetics, UBC Okanagan Supervisory Committee Member Dr. Loic Merkley, PhD, Faculty of Engineering, UBC Okanagan University Examiner ii iii Abstract Oxidative stress is ultimately determined by the balance between pro- (e.g. free radicals) and antioxidants (e.g. vitamin C). The purpose of this thesis was to examine the role and effect of a combined mixture of oral antioxidants (vitamin C, E, and alpha-lipoic acid) on peripheral and cerebrovascular regulation at both sea-level (344m; n = 11 participants) and at high altitude (5050m; n=10) where oxidative stress is markedly elevated. In a randomized and double-blinded design, flow-mediated dilation, cardiorespiratory, cerebral blood flow, and CO2 and hypoxic cerebrovascular reactivity tests were conducted before and 90 mins following antioxidants (vitamin C, E, and alpha-lipoic acid) or a placebo control, previous work has shown antioxidant levels increased in blood plasma after 90 mins of ingestion. Following 10-12 days at 5050m, in a similar design, flow-mediated dilation, …
has type: Thesis/Dissertation
date issued: 2017-11
is shown at: 10.14288/1.0357170
language: eng
degree discipline: Interdisciplinary Studies
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/63341