Remotely controlled drug delivery systems
department or school: Applied Science, Faculty of
department or school: Engineering, School of (Okanagan)
data provider: DSpace
degree campus: UBCO
creator: Zaher, Amir
issued: 2016-04-15T03:16:51
issued: 2016
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Implantable drug delivery is becoming an increasingly important field of research, providing great potential for a wide range of flexible and low cost solutions for localized treatment of chronically debilitating diseases. This dissertation presents work that encompasses several approaches for the remote triggering, powering, and control of micro drug delivery devices and systems, designed with remote-controllability, minimal power requirements, biocompatibility, and the potential for minimally invasive implantation in mind. The control mechanisms used rely on microtechnology, nanotechnology, and electromagnetic power transfer to magnetic nanoparticles and magnetic nanowires, for the heating and actuation of thermoresponsive Poly(N-isopropylacrylamide) hydrogels (PNIPAm) in the form of nanoparticles in membranes and stand-alone microdroplets, and actuation of flexible membranes for drug pumping. Thermoresponsive PNIPAm, in any form such as nanoparticles, microdroplets, or mezzo scale bulk material shapes, has the property of swelling with water in its hydrophilic state below a critical temperature. At higher temperatures, a sharp change occurs, the polymer network becomes hydrophilic, and the water molecules in the network is expelled, causing the overall material to shrink in size, while the released water or aqueous solution is left free to flow around or away from the material. When embedded in membrane matrices used as drug delivery gates, PNIPAm nanoparticles act as diffusion and flow blockers below the critical temperature. When PNIPAm surpasses the critical temperature, induced by heat from local magnetic iron oxide nanoparticles (exposed to a 62 mT, 450 kHz magnetic field), it shrinks in size and increases the drug flow through membrane pathways. The combination of this membrane design with osmotic pumping and methods for tailoring the drug release profile is reported. Simulation supports experimental results while describing interactions between the osmotic…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/57611
note: REMOTELY CONTROLLED DRUG DELIVERY SYSTEMS by Amir Zaher A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE COLLEGE OF GRADUATE STUDIES (Engineering) THE UNIVERSITY OF BRITISH COLUMBIA (Okanagan) March 2016 © Amir Zaher, 2016 The undersigned certify that they have read, and recommend to the College of Graduate Studies for acceptance, a thesis entitled: Remotely Controlled Drug Delivery Systems Submitted by Amir Zaher in partial fulfillment of the requirements of The degree of Doctor of Philosophy . Dr. Ian Foulds, School of Engineering Supervisor, Professor (please print name and faculty/school above the line) Dr. Jürgen Kosel, King Abdullah University of Science and Technology Supervisory Committee Member, Professor (please print name and faculty/school in the line above) Dr. Keekyoung Kim, School of Engineering Supervisory Committee Member, Professor (please print name and faculty/school in the line above) Dr. Rudolf Seethaler, School of Engineering University Examiner, Professor (please print name and faculty/school in the line above) Dr. Bethanie Stadler, University of Minnesota External Examiner, Professor (please print name and university in the line above) April 1, 2016 (Date submitted to Grad Studies) ii Abstract Implantable drug delivery is becoming an increasingly important field of research, providing great potential for a wide range of flexible and low cost solutions for localized treatment of chronically debilitating diseases. This dissertation presents work that encompasses several approaches for the remote triggering, powering, and control of micro drug delivery devices and systems, designed with remote-controllability, minimal power requirements, biocompatibility, and the potential for minimally invasive implantation in mind. The control mechanisms used rely on microtechnology, nanotechnology, and electromagnetic power transfer to magnetic nanoparticles and magnetic nanowires, for the heating an…
has type: Thesis/Dissertation
date issued: 2016-05
is shown at: 10.14288/1.0300659
language: eng
degree discipline: Electrical Engineering
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/57611