Characterization of myelin water imaging using a gradient and spin echo sequence in human brain and spinal cord
department or school: Science, Faculty of
department or school: Physics and Astronomy, Department of
data provider: DSpace
degree campus: UBCV
creator: Ljungberg, Emil
issued: 2016-04-18T18:14:33Z
issued: 2016
related degree: Master of Applied Science - MASc
degree grantor: University of British Columbia
description: Myelin water imaging is a quantitative magnetic resonance imaging technique that can be used as an in vivo biomarker for myelin in the central nervous system. In 2007, a paradigm shift took place when the standard sequence for myelin water imaging changed from a multi-echo spin echo sequence to a gradient and spin echo (GRASE) sequence. The GRASE sequence has so far only been applied to brain imaging, and reproducibility between different scan vendors has not been assessed. In this study I present the first implementation of myelin water imaging using GRASE in human cervical spinal cord. The reproducibility of myelin water imaging in the spinal cord was found to be high (coefficient of variation = 6.1%, Cronbach’s α = 0.89). A multicenter reproducibility study of myelin water imaging in brain between two scan vendors (Siemens and Philips) was also performed. Results from the two scanners were found to be highly correlated but with a significant offset in myelin water fraction of 4.3%. Together, these two studies provide strong evidence of the reproducibility of myelin water imaging. It is an important step forward in the development of bringing myelin water imaging to the mainstream.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/57670
note: Characterization of Myelin Water Imaging Using a Gradient and SpinEcho Sequence in Human Brain and Spinal CordbyEmil LjungbergB.Sc., Lund University, 2013A THESIS SUBMITTED IN PARTIAL FULFILLMENTOF THE REQUIREMENTS FOR THE DEGREE OFMaster of Applied ScienceinTHE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES(Engineering Physics)The University of British Columbia(Vancouver)April 2016c© Emil Ljungberg, 2016AbstractMyelin water imaging is a quantitative magnetic resonance imaging technique that can be usedas an in vivo biomarker for myelin in the central nervous system. In 2007, a paradigm shift tookplace when the standard sequence for myelin water imaging changed from a multi-echo spin echosequence to a gradient and spin echo (GRASE) sequence. The GRASE sequence has so far onlybeen applied to brain imaging, and reproducibility between different scan vendors has not beenassessed. In this study I present the first implementation of myelin water imaging using GRASEin human cervical spinal cord. The reproducibility of myelin water imaging in the spinal cord wasfound to be high (coefficient of variation = 6.1%, Cronbach’s α = 0.89). A multicenter repro-ducibility study of myelin water imaging in brain between two scan vendors (Siemens and Philips)was also performed. Results from the two scanners were found to be highly correlated but witha significant offset in myelin water fraction of 4.3 %. Together, these two studies provide strongevidence of the reproducibility of myelin water imaging. It is an important step forward in thedevelopment of bringing myelin water imaging to the mainstream.iiPrefaceThe work presented in this thesis was carried out at the MRI Research Centre at the University ofBritish Columbia between May 2015 and April 2016. In addition to the formal supervision by Dr.Alex MacKay, I also received very helpful supervision from Dr. Shannon Kolind.The data presented in chapter 2 was collected and analyzed by the author Emil Ljungbergduring the fall of 2015 and …
has type: Thesis/Dissertation
date issued: 2016-05
is shown at: 10.14288/1.0228626
language: eng
degree discipline: Engineering Physics
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/57670