Wireless MEMS drug delivery device enabled by a micromachined Nitinol actuator as a pumping mechanism
department or school: Applied Science, Faculty of
department or school: Electrical and Computer Engineering, Department of
data provider: DSpace
degree campus: UBCV
creator: Fong, Jeffrey Chun Kit
issued: 2015-01-06T21:47:11Z
issued: 2014
related degree: Master of Applied Science - MASc
degree grantor: University of British Columbia
description: Traditional drug delivery methods utilize systemic administration where the medication is circulated through the entire body. These methods require a high dosage at the point of entry in order to reach the therapeutic level at the targeted location and can result in serious side effects. Implantable drug delivery devices can be used to increase efficacy by targeting specific regions in the body and by safely using higher drug concentrations. Microfabrication allows for the creation of these minimally invasive devices to treat conditions not previously possible due to the limited amount of space surrounding the target area. Devices with passive releasing mechanisms have been commercialized but ones with active mechanisms are still in the works. In this thesis, a shape memory alloy (SMA) actuator is micromachined into a rectangular, planar coil to perform cantilever-like actuation. The SMA-coil actuator forms a passive resonant circuit that functions as a wireless heat source activated using external radio-frequency (RF) electromagnetic fields. SiO₂ stress layers are selectively patterned on the Nitinol SMA structure to manipulate the cantilever profile at the nominal cold state. RF radiation with varying field frequencies showed strong frequency dependence of wireless heating, actuation displacement, and force generation by several actuators with resonant frequencies of 170-245 MHz. When excited at resonance, these actuators exhibited maximum out-of-plane displacement and force of 215 µm and 71 mN, respectively. The actuator was integrated into a 10.0×10.5×2.1 mm³ polyimide-packaged chip containing a micromachined Parylene-C pump chamber to force the release of the drug from the reservoir by wirelessly activating the actuator. Experimental operation of the prototypes showed successful release of the test agents from devices placed in liquid and excited by radiating tuned RF fields with an output power of 1.1 W. These tests revealed a single release volume of 219 nL, …
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/51782
note: Wireless MEMS drug delivery device enabled by a micromachined Nitinol actuator as a pumping mechanism by Jeffrey Chun Kit Fong B.Sc. Engineering Physics, University of Alberta, 2012 A thesis submitted in partial fulfillment of the requirements for the degree of Master of Applied Science in The Faculty of Graduate and Postdoctoral Studies (Electrical & Computer Engineering) The University of British Columbia (Vancouver) December 2014 © Jeffrey Chun Kit Fong, 2014 ii Abstract Traditional drug delivery methods utilize systemic administration where the medication is circulated through the entire body. These methods require a high dosage at the point of entry in order to reach the therapeutic level at the targeted location and can result in serious side effects. Implantable drug delivery devices can be used to increase efficacy by targeting specific regions in the body and by safely using higher drug concentrations. Microfabrication allows for the creation of these minimally invasive devices to treat conditions not previously possible due to the limited amount of space surrounding the target area. Devices with passive releasing mechanisms have been commercialized but ones with active mechanisms are still in the works. In this thesis, a shape memory alloy (SMA) actuator is micromachined into a rectangular, planar coil to perform cantilever-like actuation. The SMA-coil actuator forms a passive resonant circuit that functions as a wireless heat source activated using external radio-frequency (RF) electromagnetic fields. SiO2 stress layers are selectively patterned on the Nitinol SMA structure to manipulate the cantilever profile at the nominal cold state. RF radiation with varying field frequencies showed strong frequency dependence of wireless heating, actuation displacement, and force generation by several actuators with resonant frequencies of 170-245 MHz. When excited at resonance, these actuators exhibited maximum out-of-plane displacement and force of 215 µm and 71 mN…
has type: Thesis/Dissertation
date issued: 2015-02
is shown at: 10.14288/1.0167648
language: eng
degree discipline: Electrical and Computer Engineering
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivs 2.5 Canada
rights URI: http://creativecommons.org/licenses/by-nc-nd/2.5/ca/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/51782